Thiouracil

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Thiouracil
Thiouracil.png
Identifiers
CAS number 141-90-2 YesY
PubChem 1269845
ChemSpider 1066108 YesY
UNII 59X161SCYL YesY
KEGG C19304 N
MeSH Thiouracil
ChEBI CHEBI:348530 YesY
ChEMBL CHEMBL345768 YesY
Jmol-3D images Image 1
Properties
Molecular formula C4H4N2OS
Molar mass 128.15 g mol−1
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N (verify) (what is: YesY/N?)
Infobox references

Thiouracil refers both to a specific molecule consisting of a sulfated uracil, and a family of molecules based upon that structure. The substance is a historically relevant antithyroid preparation. Astwood E.B. used it in 1943 as therapy of Graves' disease for the first time.[1] It remains in use.

Thiouracil inhibits thyroid activity by blocking the enzyme thyroid peroxidase.[2]

References[edit]

  1. ^ Gerabek, W. (2005). Enzyklopädie Medizingeschichte. p. 152. ISBN 9783110157147. 
  2. ^ Nagasaka, A.; Hidaka, H. (1976). "Effect of Antithyroid Agents 6-Propyl-2-Thiouracil and l-Methyl-2-Mercaptoimidazole on Human Thyroid Iodide Peroxidase". Journal of Clinical Endocrinology & Metabolism 43 (1): 152–8. doi:10.1210/jcem-43-1-152. PMID 947933.