Thiram

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Thiram
Thiram.png
Identifiers
CAS number 137-26-8 YesY
PubChem 5455
ChemSpider 5256 N
KEGG D06114 YesY
ChEBI CHEBI:9495 N
ATC code P03AA05
Jmol-3D images Image 1
Properties
Molecular formula C6H12N2S4
Molar mass 240.43 g mol−1
Appearance White to yellow crystalline powder
Melting point 155 to 156 °C (311 to 313 °F; 428 to 429 K)
Solubility in water 30 mg/L
Hazards
Flash point 138 °C (280 °F)[1]
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N (verify) (what is: YesY/N?)
Infobox references

Thiram is an ectoparasiticide. It is used to prevent fungal diseases in seed and crops. It is also used as an animal repellent to protect fruit trees and ornamentals from damage by rabbits, rodents and deer. It is effective against Stem gall of coriander, damping off, smut of millet, neck rot of onion, etc. Thiram has been used in the treatment of human scabies, as a sun screen and as a bactericide applied directly to the skin or incorporated into soap.[2]

Chemical properties[edit]

Thiram is a type of sulfur fungicide. It has been found to dissolve completely in chloroform, acetone and ether. It is available as dust, flowable, wettable powder, water dispersible granules, and water suspension formulations and in mixtures with other fungicides.[2]

Thiram is nearly immobile in clay soils or in soils of high organic matter. It is not expected to contaminate groundwater because of its in-soil half life of 15 days and tendency to stick to soil particles.[3]

Acute toxicity[edit]

Thiram is moderately toxic by ingestion, but it is highly toxic if inhaled. Acute exposure in humans may cause headaches, dizziness, fatigue, nausea, diarrhea and other gastrointestinal complaints.[4]

Thiram is irritating to the eyes, skin and respiratory tract. It is a skin sensitizer. Symptoms of acute inhalation exposure to thiram include itching, scratchy throat, hoarseness, sneezing, coughing, inflammation of the nose or throat, bronchitis, dizziness, headaches, fatigue, nausea, diarrhea and other gastro-intestinal complaints. Persons with chronic respiratory or skin disease are at increased risk from exposure to thiram.

Chronic toxicity[edit]

In addition to the symptoms of acute exposure, symptoms of chronic exposure to thiram in humans include drowsiness, confusion, loss of sex drive, incoordination, slurred speech and weakness. Repeated or prolonged exposure to thiram can also cause allergic reactions such as dermatitis, watery eyes, sensitivity to light and conjunctivitis.[5]

Metabolic effects[edit]

Thiram has been described to interfere with glucocorticoid metabolism, by inhibiting the activity of the enzyme 11beta-hydroxysteroiddehydrogenase type 2, which converts cortisol to cortisone.[6]

References[edit]

  1. ^ U.S. Department of Agriculture, Soil Conservation Service. 1990 (Nov). SCS/ARS/CES Pesticide Properties Database: Version 2.0 (Summary). USDA - Soil Conservation Service, Syracuse, NY.
  2. ^ a b "Thiram". Extension Toxicology Network. 
  3. ^ Howard, P.H., ed. (1989). Handbook of Environmental Fate and Exposure Data for Organic Chemicals. Vol. III: Pesticides. Chelsea, MI: Lewis Publishers. 
  4. ^ Hayes, W.J. and E.R. Laws, ed. (1990). Handbook of Pesticide Toxicology. Vol. 3, Classes of Pesticides. NY: Academic Press, Inc. 
  5. ^ CDC - NIOSH Pocket Guide to Chemical Hazards
  6. ^ Atanasov AG, Tam S, Röcken JM, Baker ME,Odermatt A. Inhibition of 11beta-hydroxysteroid dehydrogenase type 2 bydithiocarbamates. Biochem Biophys ResCommun. 2003 Aug 22;308(2):257-62. PubMedPMID 12901862. http://www.ncbi.nlm.nih.gov/pubmed/12901862

External links[edit]