|Born||August 17, 1798
Pentonville, St. James Parish, Middlesex
|Died||April 5, 1866
|Known for||preventive medicine|
Thomas Hodgkin (1798 – 1866) was an English physician, considered one of the most prominent pathologists of his time and a pioneer in preventive medicine. He is now best known for the first account of Hodgkin's disease, a form of lymphoma and blood disease, in 1832. Hodgkin's work marked the beginning of times when a pathologist was actively involved in the clinical process. He was a contemporary of Thomas Addison and Richard Bright at Guy's Hospital.
Early life 
Thomas Hodgkin was born to a Quaker family in Pentonville, St. James Parish, Middlesex, the son of John Hodgkin. He received private education with his brother John Hodgkin, and in 1816 took a position as private secretary to William Allen. His aim, however, was to learn the trade of apothecary, one of the routes into medicine, and Allen, despite prominence in that business, did not make it possible. They parted, and Hodgkin went to an apothecary cousin, John Glaisyer, in Brighton instead. He inherited property from his great-uncle of the same name, meaning that from age 21 he had a degree of financial independence.
Medical training and travel 
In September 1819 Hodgkin was admitted to St. Thomas's and Guy's Medical School. He "walked the wards" for a year on the rounds of physicians and surgeons, and attended lectures, in particular those by Astley Cooper. He then studied at the University of Edinburgh, where the lecturers who impressed him included Andrew Duncan, the younger, and Robert Jameson in natural history. His first published paper, on the spleen, came from Duncan's course, and drew on the veterinary writings of his friend Bracy Clark.
In 1821, Hodgkin went to France, where he learned to work with the stethoscope, a recent invention of René Laënnec. He also took account of the exacting statistical and clinical approach of Pierre Charles Alexandre Louis. He associated there with British expatriates including Robert Knox and Helen Maria Williams. In 1823, he qualified for his M.D. at the University of Edinburgh Medical School with a thesis on the physiological mechanisms of absorption in animals.
In Paris Hodgkin met Benjamin Thorpe, a banker for Rothschild's at the time, who was suffering from tuberculosis. Hodgkin became his physician for a while, and Thorpe was cured. This contact led to another appointment as physician to Abraham Montefiore, married to Henriette, daughter of Mayer Amschel Rothschild. Once graduated at Edinburgh, Hodgkin joined the couple for travel in Italy. Abraham was seriously ill with tuberculosis (he died in 1824) and the position proved unsatisfactory for both sides, with Hodgkin dismissed. But the relationship he built up with Moses Montefiore, Abraham's brother, proved a lifelong friendship.
Staying in Paris for an extended period from September 1824 to June 1825, Hodgkin made significant medical contacts. The Edwards brothers, William-Frédéric Edwards and Henri Milne Edwards, were both physiologists with distinctive theories, and Hodgkin looked over their work in the next few years. Achille-Louis Foville was a neurologist, around whom Hodgkin tried unsuccessfully, from 1838, to set up a southern version of the York Retreat.
Career at Guy's 
Hodgkin found a position at Guy's, first as a volunteer clerk in 1825, and then in 1826 as the curator of the museum there, also carrying out autopsies. He built up his reputation on the work his posts brought him in morbid anatomy (anatomical pathology as it is now called).
Hodgkin's hospital career came to an end, however, in 1837, when he clashed with the autocratic Benjamin Harrison. Harrison disliked Hodgkin's progressive views, and support for the new University College, London, and had been personally offended by them in one instance (see below). There were two confrontational interviews in which Harrison went over pretexts for not giving Hodgkin a promotion (to Assistant Physician); Hodgkin had also been ill not long before. His friends pushed the issue to an acrimonious vote of the governors, which was in fact hopeless. The position went to the rival candidate Benjamin Guy Babington, and Hodgkin moved reluctantly into private practice, after a period of convalescence.
Lecturer at St. Thomas's 
Hodgkin had a further period of involvement with hospital medicine, when in 1842 he was asked to take charge of teaching at St. Thomas's Hospital. After joint management of Guy's and St. Thomas's had ended in 1825, St. Thomas's had found itself eclipsed as a medical school by its former partner. Hodgkin was brought in, and found new lecturers in Marshall Hall and George Gregory; he lectured himself, and with Charles Barker the four embarked on a lecture series. He also drew on his experience at Guy's to improve the museum and start a Clinical Society for reporting of cases. The outcome, however, was unsatisfactory for him. Hall was much preferred as lecturer, and Gregory, lecturing on skin diseases, gained a reputation for clarity, and wrote a textbook. But Hodgkin was not asked to continue lecturing for another year, ending the relationship.
Last years 
Hodgkin married in 1850 Sarah Frances Scaife, a widow; they had no children. When Lady Montefiore died in 1862, Hodgkin promised her to travel with her husband on future journeys. He accompanied Moses Montefiore to Palestine in 1866. There he contracted dysentery and died on 4 April 1866. He was buried in Jaffa.
Hodgkin like many other Quakers was concerned both with the abolition of slavery and the reduction of the impact of western colonization on indigenous peoples around the world. He stood aside from the Anti-Slavery Society of the 1820s and 1830s, however; the Society took a different line on emancipation and colonization in Africa. It refused in the early 1830s to publish his views. Hodgkin began to take multiple initiatives of his own.
Hodgkin had an interest in both the physical anthropology and the cultural aspects of what would now be ethnology, before the academic disciplines existed. In his role as keeper of the Museum at Guy's, he collected specimens from peoples from around the world. In 1827, in a letter supporting the missionary Hannah Kilham who was working with West African languages, he published for the first time long-held ideas on "civilisation"; a Civilization Society in London had been a Hodgkin family initiative some years earlier. In helping to found the Aborigines Protection Society, he argued that languages constituted philological evidence of man's origins, and should therefore be preserved where threatened; he had written a paper on the topic, and proposed a questionnaire, for the Philological Society in 1835.
For Hodgkin, language was a racial trait. In Paris around the end of 1838, he prevailed upon W. F. Edwards to form a French society with the same aims as the Aborigines Protection Society; and in 1839 the Société Ethnologique de Paris was set up in accordance with Edwards's own ideas. This development was reflected in 1843 when the Ethnological Society of London was set up, diverging from the Aborigines Protection Society by its scientific and linguistic interests, and disconnecting from missionary work.
Colonization in Africa 
Hodgkin was a supporter of Liberia in the early days of its foundation; and he compared it favourably to Sierra Leone. In supporting Elliott Cresson and the American Colonization Society, he put himself outside the mainstream of Quaker and abolitionist thinking. When William Lloyd Garrison toured in England in 1833, Hodgkin tried at first to mediate between Garrison and Cresson. The formation, however, of the British African Colonization Society by Cresson had Hodgkin's support, and he found himself isolated from natural allies who were Quakers or physicians. There were personal attacks on Hodgkin from the Garrison camp.
Hudson's Bay Company 
Hodgkin became involved in campaigning concerning the Boothia Peninsula and the Hudson's Bay Company around 1836–7, through his friend Richard King. King had been on the expedition of Captain George Back in the north of Canada of 1833–5, and had written an 1836 book, his Narrative, on it; he advocated a further expedition in the same area in 1836–7, a cause Hodgkin took up. Sensitive commercial interests were involved, as the Hudson's Bay Company's license was due for renewal in 1841. The Narrative contained a piece Hodgkin had written on the indifference of the Company to the indigenous peoples of western Canada. Hodgkin then took up the behaviour of the Company with Benjamin Harrison, Treasurer of Guy's, disastrously mixing his professional life with his activism: Harrison was concerned in the management of the Company as Deputy Chairman, and was related by marriage to John Henry Pelly, the Chairman, who had crossed swords with King at parliamentary hearings.
Hodgkin's concerns over the indigenous peoples in the Hudson's Bay Company territory in western Canada continued. They were pursued both by correspondence with Sir George Simpson, and in the pages of the Intelligencer of the Aborigines Protection Society.
Work in medicine 
Hodgkin collaborated with Joseph Jackson Lister, who in 1830 enunciated design principles for the achromatic microscope. By that time Hodgkin and Lister had already published research on tissue samples, based on observations made with Lister's innovative microscope, in particular on the "globule hypothesis" of the time which was held in particular by Henri Milne Edwards. They denied the existence of globules in tissue; Ernst Heinrich Weber in 1830 contradicted them, and the debate continued for a decade. For a while microscopy suffered in its reputation, but by 1840 histology was a recognised discipline, and in time the view of Hodgkin and Lister that "globules" were optical artefacts became accepted. The 1827 paper they published has been called "the foundation of modern histology".
Hodgkin described the disease that bears his name (Hodgkin's lymphoma) in 1832, in a paper titled On Some Morbid Appearances of the Absorbent Glands and Spleen. He received 33 years later the eponym through the recognition of British physician Samuel Wilks, who rediscovered the disease. It is a malignancy that produces enlargement of lymphoid tissue, spleen, and liver, with invasion of other tissues. A more benign form is called Hodgkin's paragranuloma, while a more invasive form is called Hodgkin's sarcoma.
Hodgkin published as a book his Lectures on Morbid Anatomy in 1836 and 1840. His major contribution to the teaching of pathology, however, was made in 1829, with his two volumed work entitled The Morbid Anatomy of Serous and Mucous Membranes, which became a classic in modern pathology.
Hodgkin was one of the earliest defenders of preventive medicine, having published On the Means of Promoting and Preserving Health in book form in 1841. Among other early observations were the first description of acute appendicitis, of the biconcave format of red blood cells and the striation of muscle fibers.
Hodgkin also translated with Thomas Fisher, from the French of William-Frédéric Edwards, On the Influence of Physical Agents on Life (London, 1832; Philadelphia 1838). Edwards was a vitalist in physiology, who studied the effect of physical forces on processes in living organisms. The work as it appeared in English was much more than a translation, since it contained an appendix of over 200 pages containing two dozen papers, a compendium of medicine and science tangentially related to themes in Edwards, but related to his general approach. It included early work by Hodgkin and collaboration with Lister, as well as something on electricity and meteorology. He also published The Means of Promoting and Preserving Health (London, 1840), of which a second edition appeared in 1841, and an Address on Medical Reform (1847).
Other works 
Other works by Hodgkin were Biographical Sketches of James Cowles Prichard (1849), and William Stroud (1858). He also wrote abolitionist pamphlets and on the British African Colonization Societies (1833–1834).
- Amalie M. Kass and Edward H. Kass (1988), Perfecting the World: The life and times of Dr. Thomas Hodgkin, 1798–1866, Boston, Harcourt Brace Jovanovic, 1988. ISBN: 9780151717002
- "Hodgkin, Thomas". Dictionary of National Biography. London: Smith, Elder & Co. 1885–1900.
- Kass, Amalie M. "Hodgkin, Thomas". Oxford Dictionary of National Biography (online ed.). Oxford University Press. doi:10.1093/ref:odnb/13429. (subscription or UK public library membership required)
- Kass & Kass, p. 27.
- Kass & Kass, p. 36.
- Kass & Kass, pp. 61–3.
- Kass & Kass, pp. 70–2.
- Kass & Kass, pp. 89–90.
- Kass & Kass, pp. 92–3.
- Kass & Kass, pp. 109–114.
- Kass & Kass, pp. 101–3.
- Kass & Kass, pp. 117–22.
- Kass & Kass, p. 129.
- Kass & Kass, pp. 323–4.
- Kass & Kass, p. 139–41.
- Kass & Kass, p. 279–95.
- Kass & Kass, p. 332–5.
- Brunton, Deborah. "Gregory, George". Oxford Dictionary of National Biography (online ed.). Oxford University Press. doi:10.1093/ref:odnb/11464. (subscription or UK public library membership required)
- Kess & Kass, pp. 487–9.
- Kass & Kass, p. 227.
- Kass & Kass, p. 167.
- Kass & Kass, p. 183.
- Kass & Kass, pp. 97–100.
- Kass & Kass, pp. 216–7.
- Philip D. Curtin (15 May 1973). The Image of Africa: British Ideas and Action, 1780-1850. Univ of Wisconsin Press. p. 331. ISBN 978-0-299-83026-7. Retrieved 29 May 2012.
- Philip D. Curtin (15 May 1973). The Image of Africa: British Ideas and Action, 1780-1850. Univ of Wisconsin Press. p. 394. ISBN 978-0-299-83026-7. Retrieved 28 May 2012.
- Kass & Kass, p. 313.
- Kass & Kass, pp. 393–4.
- Kass & Kass, pp. 222–3.
- Kass & Kass, pp. 229–33.
- Peter Warren Dease; William Barr (23 January 2002). From Barrow to Boothia: The Arctic Journal of Chief Factor Peter Warren Dease, 1836-1839. McGill-Queens. pp. 5–6. ISBN 978-0-7735-2253-4. Retrieved 27 May 2012.
- Kass & Kass, p. 259.
- Kass & Kass, p. 277.
- Clinical and Investigative Medicine, abstract, P. Warren, Thomas Hodgkin. 1798-1866. Health advocate for Manitoba Vol 30, No 4 (2007) Supplement.
- Turner, G. L'E. "Lister, Joseph Jackson". Oxford Dictionary of National Biography (online ed.). Oxford University Press. doi:10.1093/ref:odnb/16762. (subscription or UK public library membership required)
- Kass & Kass, p. 141–5.
- Giora Hon; Jutta Schickore; Friedrich Steinle (13 February 2009). Going Amiss In Experimental Research. Springer. p. 34. ISBN 978-1-4020-8892-6. Retrieved 29 May 2012.
- Samuel H. Greenblatt (1 January 1997). A History of Neurosurgery: In Its Scientific and Professional Contexts. Thieme. pp. 132–3. ISBN 978-1-879284-17-3. Retrieved 29 May 2012.
- Brian Bracegirdle (1986). A history of microtechnique: the evolution of the microtome and the development of tissue preparation. Science Heritage Ltd. pp. 27–. ISBN 978-0-940095-00-7. Retrieved 29 May 2012.
- "On some Morbid Appearances of the Absorbent Glands and Spleen". Medico-chirurgical transactions 17: 68–114. 1832. PMC 2116706. PMID 20895597.
- On the influence of physical agents on life (1832), archive.org.
- William Frédéric Edwards (1838). On the influence of physical agents on life. Haswell, Barrington and Haswell. Retrieved 27 May 2012.
- Jeffrey P. Baker (9 May 1996). The Machine in the Nursery: Incubator Technology and the Origins of Newborn Intensive Care. JHU Press. p. 16. ISBN 978-0-8018-5173-5. Retrieved 28 May 2012.
- Kass & Kass, pp. 192–3.
Further reading 
- Jay, Venita (2005). "On a historical note: the legacy of Thomas Hodgkin". Journal of insurance medicine 37 (3): 248–9. PMID 16259216.
- Abbondanzo, Susan L (October 2003). "Thomas Hodgkin". Annals of diagnostic pathology 7 (5): 333–4. doi:10.1016/S1092-9134(03)00077-7. PMID 14571438.
- Soit, I; Ben-Arush M W (December 1998). "[Two-hundred years since the birth of Thomas Hodgkin (1798-1886)]". Harefuah 135 (11): 558–60. PMID 10911479.
- Rosenfeld, L (April 2000). "Thomas Hodgkin: social activist". Annals of diagnostic pathology 4 (2): 124–33. doi:10.1016/S1092-9134(00)90020-0. PMID 10760325.
- Watkins, S M (2000). "The legacy of Thomas Hodgkin (1798-1866)". Journal of the Royal College of Physicians of London 34 (1): 100–4. PMID 10717890.
- Jay, V (December 1999). "A portrait in history. Thomas Hodgkin". Arch. Pathol. Lab. Med. 123 (12): 1144. doi:10.1043/0003-9985(1999)123<1144:TH>2.0.CO;2. ISSN 0003-9985. PMID 10583916.
- Kass, A M (June 1999). "Thomas Hodgkin remembered". Cancer Treat. Rev. 25 (3): 133–43. doi:10.1053/ctrv.1998.0108. PMID 10447362.
- Daws, J J (June 1999). "Thomas Hodgkin and the museum at Guy's Hospital". Cancer Treat. Rev. 25 (3): 145–9. doi:10.1053/ctrv.1998.0110. PMID 10425255.
- Knight, R (June 1999). "Thomas Hodgkin bicentenary conference". Cancer Treat. Rev. 25 (3): 129–30. doi:10.1053/ctrv.1999.0112. PMID 10425252.
- Zantinga, A R; Coppes M J (August 1996). "Thomas Hodgkin (1798-1866): pathologist, social scientist, and philanthropist". Med. Pediatr. Oncol. 27 (2): 122–7. doi:10.1002/(SICI)1096-911X(199608)27:2<122::AID-MPO9>3.0.CO;2-H. PMID 8649319.
- Dubovsky, H (May 1996). "The humanitarian and scientific interests of Thomas Hodgkin (1798-1866), discoverer of a disease". S. Afr. Med. J. 86 (5): 556–8. PMID 8711558.
- Sperati, G (1994). "[Thomas Hodgkin (physician, pathologist, philanthropist, social reformer)]". Acta Otorhinolaryngologica Italica 14 (1): 81–2. PMID 8036892.
- Bloch, H (August 1993). "Thomas Hodgkin (1798-1866): physician, Quaker, social activist, and pioneer English pathologist". South. Med. J. 86 (8): 945–7. doi:10.1097/00007611-199308000-00018. PMID 8351558.
- Rosenfeld, L (1991). "Thomas Hodgkin and Moses Montefiore; Europe, Asia, and Africa". Bulletin of the New York Academy of Medicine 67 (5): 460–74. PMC 1807981. PMID 1933071.
- Cuddihy, J (May 1991). "Thomas Hodgkin". Cancer Cells 3 (5): 200–2. PMID 1892730.
- Hancock, B W (August 1990). "Early clinical pathologists. 2. Thomas Hodgkin: pathologist, physician, and philanthropist". J. Clin. Pathol. 43 (8): 616–8. doi:10.1136/jcp.43.8.616. PMC 502638. PMID 2205633.
- Rosenfeld, L (May 1988). "Thomas Hodgkin: the Southern Retreat and the Oxford case". Bulletin of the New York Academy of Medicine 64 (4): 335–46. PMC 1629344. PMID 3069164.
- Rosenfield, L (March 1988). "Thomas Hodgkin and 1832: cholera, colonization, and child labor". Bulletin of the New York Academy of Medicine 64 (2): 184–99. PMC 1629321. PMID 3073833.
- Kass, A M (February 1988). "Saving the Maoris: Dr Thomas Hodgkin as a physician and social reformer". N. Z. Med. J. 101 (840): 82–6. PMID 3288918.
- Hoerni, B (1988). "[Thomas Hodgkin]". Bulletin du cancer 75 (2): 233–5. PMID 3282580.
- Rosenfeld, L (November 1986). "Thomas Hodgkin and Benjamin Guy Babington: friendly rivals and career parallels". Bulletin of the New York Academy of Medicine 62 (9): 910–7. PMC 1629151. PMID 3542096.
- Aterman, K (April 1986). "Thomas Hodgkin (1798-1866)". The American Journal of dermatopathology 8 (2): 157–67. doi:10.1097/00000372-198604000-00012. PMID 3521365.
- Rosenfeld, L (March 1986). "Thomas Hodgkin (1798-1866): morbid anatomist and social activist". Bulletin of the New York Academy of Medicine 62 (2): 193–205. PMC 1629089. PMID 3516286.
- Alcalay, J; Ingber A (August 1985). "Thomas Hodgkin in Jewish history". The American Journal of dermatopathology 7 (4): 402–3. doi:10.1097/00000372-198508000-00020. PMID 3916270.
- Kass, A M; Kass E H (July 1985). "The Thomas Hodgkin portraits: a case of mistaken identity". Medical history 29 (3): 259–63. PMC 1139540. PMID 3892196.
- Kass, A M (October 1983). "Dr Thomas Hodgkin, Dr Martin Delany, and the "return to Africa"". Medical history 27 (4): 373–93. PMC 1140045. PMID 6358725.
- Björkholm, M (February 1983). "[The man behind the syndrome: Thomas Hodgkin. An impulsive pioneer of pathology and fighter for justice for the poor]". Lakartidningen 80 (5): 334–5. PMID 6343738.
- Kass, A M; Kass E H (September 1981). "Doctors afield. Martin Delany, Thomas Hodgkin, and the Black Nationalist movement". N. Engl. J. Med. 305 (12): 682–4. doi:10.1056/NEJM198109173051207. PMID 7022212.
- Kass, E H; Carey A B, Kass A M (April 1980). "Thomas Hodgkin and Benjamin Harrison: crisis and promotion in academia". Medical history 24 (2): 197–208. PMC 1082704. PMID 6990129.
- Cherry, C L (July 1979). "The Southern Retreat, Thomas Hodgkin, and Achille-Louis Foville". Medical history 23 (3): 314–24. PMC 1082477. PMID 395377.
- Sakula, A (May 1979). "Dr Thomas Hodgkin and Sir Moses Montefiore Bart--the friendship of two remarkable men". Journal of the Royal Society of Medicine 72 (5): 382–7. PMC 1436892. PMID 399638.
- Brian, V A (September 1976). "Thomas Hodgkin 1798-1866". Nursing times 72 (37): 1451. PMID 785399.
- Lyons, J B (July 1976). "Pioneers in medicine: Thomas Hodgkin, 1798-1866". Nursing mirror and midwives journal 143 (4): 46. PMID 785404.
- Friedman, B (July 1975). "Thomas Hodgkin - a maverick in his time". The Alabama journal of medical sciences 12 (3): 250–1. PMID 1099924.
- Hodgkin, T. (1973). "Classics in oncology. Excerpts from: On some morbid appearances of the absorbent glands and spleen, Thomas Hodgkin". CA: a cancer journal for clinicians 23 (1): 54–60. doi:10.3322/canjclin.23.1.54. PMID 4630498.
- "Thomas Hodgkin (1798-1866)". CA: a cancer journal for clinicians 23 (1): 52–3. 1973. doi:10.3322/canjclin.23.1.52. PMID 4630497.
- Cremin, B J (May 1972). "Thomas Hodgkin--the man and his times". S. Afr. Med. J. 46 (20): 621–4. PMID 4556921.
- Jarcho, S (October 1970). "An anthropological essay by Thomas Hodgkin". Bulletin of the New York Academy of Medicine 46 (10): 889–90. PMC 1749782. PMID 4917321.
- Wilks, S (January 1970). "Unpublished papers of Thomas Hodgkin". Bulletin of the New York Academy of Medicine 46 (1): 67–9. PMC 1749651. PMID 4903331.
- Savitz, H A (November 1969). "Doctor Thomas Hodgkin and Sir Moses Montefiore". Rhode Island medical journal 52 (11): 619–21. PMID 4900117.
- Kass, E H; Bartlett A H (1969). "Thomas Hodgkin, M. D. (1798-1866): an annotated bibliography". Bulletin of the history of medicine 43 (2): 138–75. PMID 4890530.
- Leibowitz, J O (1967). "Thomas Hodgkin (1798-1866)". Isr. J. Med. Sci. 3 (3): 501–4. PMID 5340967.
- Hill, W (1966). "Thomas Hodgkin--a bibliography". Guy's Hospital reports 115 (3): 281–303. PMID 5334963.
- Kass, E H (1966). "Thomas Hodgkin, physician and social scientist". Guy's Hospital reports 115 (3): 269–80. PMID 5334962.
- Hunter, R (1966). "Thomas Hodgkin, Samuel Tuke and John Conolly". Guy's Hospital reports 115 (3): 263–7. PMID 5334961.
- Hardwick, C (1966). "Thomas Hodgkin 1798-1866". Guy's Hospital reports 115 (3): 255–61. PMID 5334960.
- Foxon, G E (1966). "Thomas Hodgkin, 1798-1866. A biographical note". Guy's Hospital reports 115 (3): 243–54. PMID 5334959.
- "Thomas Hodgkin—Quaker Physician". JAMA 186 (11): 1016–7. December 1963. doi:10.1001/jama.1963.03710110068017. PMID 14066713.
- Lazarus, S (August 1963). "A Visit To The Grave Of Thomas Hodgkin". Scottish medical journal 8: 312–3. PMID 14047402.
- Zakon, S J (1956). "Thomas Hodgkin, the 90th anniversary of his death". Quarterly bulletin. Northwestern University (Evanston, Ill.). Medical School 30 (4): 362–4. PMID 13408431.
- Morrison, H (December 1954). "Doctors afield: Thomas Hodgkin". N. Engl. J. Med. 251 (23): 946–8. doi:10.1056/NEJM195412022512307. PMID 13214366.
- WhoNamedIt - Thomas Hodgkin
- History and Timeline of Hodgkin's Disease
- Claus Bernet (2008). "Thomas Hodgkin". In Bautz, Traugott. Biographisch-Bibliographisches Kirchenlexikon (BBKL) (in German) 29. Nordhausen: Bautz. cols. 662–673. ISBN 978-3-88309-452-6.