Shepherd's work, mostly topographical, is characterized by an attention to detail, along with lifelike scenes that contained people, carriages and horses. His first acclaim came with Metropolitan improvements, a publication of modern London architecture commissioned by Jones & Co. He worked mostly for Frederick Crace, who employed him to paint old London buildings prior to their demolition, with much of the work surviving in the Crace collection at the British Museum
^Note: George Shepherd and "George Sidney Shepherd" are now thought to be one and the same person, which makes T. H. Shepherd the brother, and not the son, of G. Shepherd. See George "Sidney" Shepherd (1784 – 1862) (Bedfordshire Artists).