Thorpe reaction

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The Thorpe reaction is a chemical reaction described as a self-condensation of aliphatic nitriles catalyzed by base to form enamines.[1][2][3] The reaction was discovered by Jocelyn Field Thorpe.

The Thorpe reaction

Thorpe–Ziegler reaction[edit]

The Thorpe–Ziegler reaction (named after Jocelyn Field Thorpe and Karl Ziegler), or Ziegler method, is the intramolecular modification with a dinitrile as a reactant and a cyclic ketone as the final reaction product after acidic hydrolysis. The reaction is conceptually related to the Dieckmann condensation.


  1. ^ Baron, H.; Remfry, F. G. P.; Thorpe, Y. F. (1904). "CLXXV.?The formation and reactions of imino-compounds. Part I. Condensation of ethyl cyanoacetate with its sodium derivative". J. Chem. Soc. 85: 1726. doi:10.1039/ct9048501726. 
  2. ^ Karl Ziegler et al. (1933). Ann. 504: 94.  Missing or empty |title= (help)
  3. ^ Schaefer, J. P.; Bloomfield, J. J. (1967). "The Dieckmann Condensation (Including the Thorpe-Ziegler Condensation)". Org. React. 15. p. 1. doi:10.1002/0471264180.or015.01. ISBN 0471264180. 

External links[edit]

  • Thorpe-Ziegler reaction: 4-Phosphorinanone, 1-phenyl- Organic Syntheses, Coll. Vol. 6, p.932 (1988); Vol. 53, p.98 (1973) Link