Thrombin receptor

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There are three known thrombin receptors termed PAR1, PAR3 and PAR4 (PAR for protease-activated receptor). [1]

These receptors are members of the 7 transmembrane g protein-coupled family of receptors, however, their method of activation is unique. Thrombin, a serine protease, binds to and cleaves the extracellular N-terminal domain of the receptor. A tethered ligand corresponding to the new N-terminus, SFLLRN, is then unmasked, binding to the second extracellular loop of the receptor and activating it.

References[edit]

  1. ^ "Thrombin receptors and their antagonists: an update on the patent literature.". Expert Opin Ther Pat 20 (7): 875–84. Jul 2010. doi:10.1517/13543776.2010.487864. PMID 20450349. Retrieved 8 April 2013.