Thymidine kinase 1

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Thymidine kinase 1, soluble
Protein TK1 PDB 1w4r.png
PDB rendering based on 1w4r.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols TK1 ; TK2
External IDs OMIM188300 MGI98763 HomoloGene37749 ChEMBL: 2883 GeneCards: TK1 Gene
EC number 2.7.1.21
RNA expression pattern
PBB GE TK1 202338 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7083 21877
Ensembl ENSG00000167900 ENSMUSG00000025574
UniProt P04183 P04184
RefSeq (mRNA) NM_003258 NM_001271729
RefSeq (protein) NP_003249 NP_001258658
Location (UCSC) Chr 17:
76.17 – 76.18 Mb
Chr 11:
117.82 – 117.83 Mb
PubMed search [1] [2]

Thymidine kinase 1, soluble (gene name TK1), is a human thymidine kinase.[1]

Two forms of this protein have been identified in animal cells, one in cytosol and one in mitochondria. Activity of the cytosolic enzyme is high in proliferating cells and peaks during the S-phase of the cell cycle; it is very low in resting cells.


Interactions[edit]

Thymidine kinase 1 has been shown to interact with P21.[2]

Interactive pathway map[edit]

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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FluoropyrimidineActivity_WP1601 go to article go to article go to article go to pathway article go to pathway article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to PubChem Compound go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to pathway article go to pathway article go to article go to article go to article go to article go to article go to WikiPathways go to article go to article go to article go to article go to article go to article go to article go to article go to article
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FluoropyrimidineActivity_WP1601 go to article go to article go to article go to pathway article go to pathway article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to PubChem Compound go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to pathway article go to pathway article go to article go to article go to article go to article go to article go to WikiPathways go to article go to article go to article go to article go to article go to article go to article go to article go to article
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Fluorouracil (5-FU) Activity edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601". 

References[edit]

  1. ^ "Entrez Gene: Thymidine kinase 1, soluble". 
  2. ^ Huang, D Y; Chang Z F (June 2001). "Interaction of human thymidine kinase 1 with p21(Waf1)". Biochem. J. (England) 356 (Pt 3): 829–34. doi:10.1042/0264-6021:3560829. ISSN 0264-6021. PMC 1221910. PMID 11389691. 

Further reading[edit]