Thymidine kinase from herpesvirus

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Thymidine kinase from herpesvirus
PDB 1kim EBI.jpg
Structure of thymidine kinase from herpesvirus.[1]
Identifiers
Symbol Herpes_TK
Pfam PF00693
InterPro IPR001889
SCOP 1kin
SUPERFAMILY 1kin

Thymidine kinase from herpesvirus is a sub-family of thymidine kinases.[2]

Its presence in herpesvirus-infected cells is used to activate a range of antivirals against herpes infection, and thus specifically target the therapy towards infected cells only.

Such antivirals include:

References[edit]

  1. ^ Champness JN, Bennett MS, Wien F, et al. (August 1998). "Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands". Proteins 32 (3): 350–61. doi:10.1002/(SICI)1097-0134(19980815)32:3<350::AID-PROT10>3.0.CO;2-8. PMID 9715911. 
  2. ^ Brown DG, Visse R, Sandhu G, Davies A, Rizkallah PJ, Melitz C, Summers WC, Sanderson MR (October 1995). "Crystal structures of the thymidine kinase from herpes simplex virus type-1 in complex with deoxythymidine and ganciclovir". Nat. Struct. Biol. 2 (10): 876–81. doi:10.1038/nsb1095-876. PMID 7552712.