Thymidine triphosphate

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Thymidine triphosphate
Skeletal formula of thymidine triphosphate, 3- negative charge
Space-filling model of the thymidine triphosphate molecule, 4- negative charge
Names
IUPAC name
[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl (hydroxy-phosphonooxyphosphoryl) hydrogen phosphate
Other names
dTTP, 2'-deoxythymidine triphosphate
Identifiers
365-08-2 N=
ChEMBL ChEMBL363559 N
ChemSpider 58493 N=
Jmol-3D images Image
MeSH thymidine+5'-triphosphate
PubChem 64968
Properties
C10H17N2O14P3
Molar mass 482.168
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N
Infobox references

Deoxythymidine triphosphate (dTTP) is one of the four nucleoside triphosphates that are used in the in vivo synthesis of DNA. Unlike the other deoxyribonucleotide triphosphates, thymidine triphosphate does not contain the "deoxy" prefix in its name.[1] The corresponding ribonucleoside triphosphate is called 5-methyluridine triphosphate.

It can be used by DNA ligase to create overlapping "sticky ends" so that protruding ends of opened microbial plasmids may be closed up.

References[edit]

  1. ^ Coghill, Anne M.; Garson, Lorrin R., ed. (2006). The ACS style guide: effective communication of scientific information (3rd ed.). Washington, D.C.: American Chemical Society. p. 244. ISBN 978-0-8412-3999-9.