Thymopentin

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Thymopentin
Thymopentin.png
Systematic (IUPAC) name
L-arginyl-L-lysyl-L-α-aspartyl-L-valyl-L-tyrosine
Clinical data
Identifiers
 YesY
L03AX09
PubChem CID 451417
ChemSpider 397640 YesY
UNII O3Y80ZF13F YesY
KEGG D06117 YesY
ChEMBL CHEMBL156025 YesY
NIAID ChemDB 000127
Synonyms (3S)-3-[[(2S)-6-amino-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-4-[[(2S)-1-[[(2S)-1-hydroxy-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acid
Chemical data
Formula C30H49N9O9
679.76496 g/mol
 YesY (what is this?)  (verify)

Thymopentin is an immunostimulant. As such, it has been used in several clinical studies in the early years of the AIDS pandemic (from 1983 to 1985). Thymopentin helped to improve immunological condition in several patients for a brief time under specific treatments.[1][2][3]

It interacts with T cells.[4]

It is a thymic polypeptide.[5]

References[edit]

  1. ^ Mascart-Lemone F, Huygen K, Clumeck N, Brenez D, Bolla K, Duchateau J (1983). "Stimulation of cellular function by thymopentin (TP-5) in three AIDS patients". Lancet.  322 (8352): 735–736. doi:10.1016/S0140-6736(83)92271-7. PMID 6193382. 
  2. ^ Clumeck N, Van de Perre P, Mascart-Lemone F, Cran S, Bolla K, Duchateau J (1984). "Preliminary results on clinical and immunological effects of thymopentin in AIDS". Int J Clin Pharmacol Res 4: 459–463. PMID 6398315. 
  3. ^ Clumeck N, Cran S, Van de Perre P, Mascart-Lemone F, Duchateau J, Bolla K (1985). "Thymopentin treatment in AIDS and pre-AIDS patients". Surv Immunol Res 4 (1): supp1 58–62. PMID 3898293. 
  4. ^ Liu Z, Zheng X, Wang J, Wang E (2007). Egli, Martin, ed. "Molecular analysis of thymopentin binding to HLA-DR molecules". PLoS ONE 2 (12): e1348. doi:10.1371/journal.pone.0001348. PMC 2137936. PMID 18159232.  open access publication - free to read
  5. ^ Peng Y, Chen Z, Yu W et al. (July 2008). "Effects of thymic polypeptides on the thymopoiesis of mouse embryonic stem cells". Cell biology international 32 (10): 1265–71. doi:10.1016/j.cellbi.2008.07.011. PMID 18692582.