Tight junction protein 1

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Tight junction protein 1
Protein TJP1 PDB 2h2b.png
PDB rendering based on 2h2b.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols TJP1 ; ZO-1
External IDs OMIM601009 MGI98759 HomoloGene2445 GeneCards: TJP1 Gene
RNA expression pattern
PBB GE TJP1 202011 at tn.png
PBB GE TJP1 214168 s at tn.png
More reference expression data
Species Human Mouse
Entrez 7082 21872
Ensembl ENSG00000104067 ENSMUSG00000030516
UniProt Q07157 P39447
RefSeq (mRNA) NM_001301025 NM_001163574
RefSeq (protein) NP_001287954 NP_001157046
Location (UCSC) Chr 15:
29.99 – 30.26 Mb
Chr 7:
65.3 – 65.37 Mb
PubMed search [1] [2]

Tight junction protein ZO-1 is a protein that in humans is encoded by the TJP1 gene.[1]

This gene encodes a protein located on a cytoplasmic membrane surface of intercellular tight junctions. The encoded protein may be involved in signal transduction at cell–cell junctions. Two transcript variants encoding distinct isoforms have been identified for this gene.[2]


Tight junction protein 1 has been shown to interact with:

See also[edit]


  1. ^ Mohandas TK, Chen XN, Rowe LB, Birkenmeier EH, Fanning AS, Anderson JM, Korenberg JR (February 1997). "Localization of the tight junction protein gene TJP1 to human chromosome 15q13, distal to the Prader-Willi/Angelman region, and to mouse chromosome 7". Genomics 30 (3): 594–7. doi:10.1006/geno.1995.1281. PMID 8825647. 
  2. ^ "Entrez Gene: TJP1 tight junction protein 1 (zona occludens 1)". 
  3. ^ Ebnet K, Schulz CU, Meyer Zu Brickwedde MK, Pendl GG, Vestweber D (2000). "Junctional adhesion molecule interacts with the PDZ domain-containing proteins AF-6 and ZO-1". J. Biol. Chem. 275 (36): 27979–88. doi:10.1074/jbc.M002363200. PMID 10856295. 
  4. ^ Ebnet K, Aurrand-Lions M, Kuhn A, Kiefer F, Butz S, Zander K, Meyer zu Brickwedde MK, Suzuki A, Imhof BA, Vestweber D (2003). "The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity". J. Cell. Sci. 116 (Pt 19): 3879–91. doi:10.1242/jcs.00704. PMID 12953056. 
  5. ^ a b Nielsen PA, Baruch A, Shestopalov VI, Giepmans BN, Dunia I, Benedetti EL, Kumar NM (2003). "Lens connexins alpha3Cx46 and alpha8Cx50 interact with zonula occludens protein-1 (ZO-1)". Mol. Biol. Cell 14 (6): 2470–81. doi:10.1091/mbc.E02-10-0637. PMC 194895. PMID 12808044. 
  6. ^ Giepmans BN, Moolenaar WH (1998). "The gap junction protein connexin43 interacts with the second PDZ domain of the zona occludens-1 protein". Curr. Biol. 8 (16): 931–4. doi:10.1016/S0960-9822(07)00375-2. PMID 9707407. 
  7. ^ Liu G, Kaw B, Kurfis J, Rahmanuddin S, Kanwar YS, Chugh SS (2003). "Neph1 and nephrin interaction in the slit diaphragm is an important determinant of glomerular permeability". J. Clin. Invest. 112 (2): 209–21. doi:10.1172/JCI18242. PMC 164293. PMID 12865409. 
  8. ^ Huber TB, Schmidts M, Gerke P, Schermer B, Zahn A, Hartleben B, Sellin L, Walz G, Benzing T (2003). "The carboxyl terminus of Neph family members binds to the PDZ domain protein zonula occludens-1". J. Biol. Chem. 278 (15): 13417–21. doi:10.1074/jbc.C200678200. PMID 12578837. 
  9. ^ Yamamoto T, Harada N, Kawano Y, Taya S, Kaibuchi K (1999). "In vivo interaction of AF-6 with activated Ras and ZO-1". Biochem. Biophys. Res. Commun. 259 (1): 103–7. doi:10.1006/bbrc.1999.0731. PMID 10334923. 
  10. ^ a b Fanning AS, Jameson BJ, Jesaitis LA, Anderson JM (1998). "The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeleton". J. Biol. Chem. 273 (45): 29745–53. doi:10.1074/jbc.273.45.29745. PMID 9792688. 
  11. ^ Rao RK, Basuroy S, Rao VU, Karnaky Jr KJ, Gupta A (2002). "Tyrosine phosphorylation and dissociation of occludin-ZO-1 and E-cadherin-beta-catenin complexes from the cytoskeleton by oxidative stress". Biochem. J. 368 (Pt 2): 471–81. doi:10.1042/BJ20011804. PMC 1222996. PMID 12169098. 
  12. ^ a b Wittchen ES, Haskins J, Stevenson BR (1999). "Protein interactions at the tight junction. Actin has multiple binding partners, and ZO-1 forms independent complexes with ZO-2 and ZO-3". J. Biol. Chem. 274 (49): 35179–85. doi:10.1074/jbc.274.49.35179. PMID 10575001. 
  13. ^ Itoh M, Morita K, Tsukita S (1999). "Characterization of ZO-2 as a MAGUK family member associated with tight as well as adherens junctions with a binding affinity to occludin and alpha catenin". J. Biol. Chem. 274 (9): 5981–6. doi:10.1074/jbc.274.9.5981. PMID 10026224. 

Further reading[edit]