In the late 1960s, Fulwood was the house drummer for the Uptown Theater in Philadelphia when he met guitarist Eddie Hazel. Hazel and bassist Billy Bass Nelson were on tour as musical support for the doo wop vocal group The Parliaments. Hazel and Nelson convinced group leader George Clinton to add Fulwood to the group, where he replaced drummer Harvey McGee. Fulwood, Hazel, and Nelson formed the core of the The Parliaments musical backing group, which later became known as Funkadelic. Fulwood also played drums in the Tyrone Davis band and the Chairmen of the Board between stints with P-Funk, and later was briefly employed by Miles Davis. Fulwood was officially dismissed from Parliament-Funkadelic in 1973. While living in Washington, D.C., Fulwood formed his own band (Tiki) with the help of a young friend, Wilbur Harris, who knew a lot of young musicians. They finished an album that was never released.
Fulwood fathered one child, Stuff Nicole Cleague, who resides in Buffalo, New York. She accepted his award at the Rock and Roll Hall of Fame in 1997 and was introduced by George Clinton. Fulwood died of stomach cancer in 1979.