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Systematic (IUPAC) name
Clinical data
AHFS/Drugs.com International Drug Names
Legal status
Routes Oral
CAS number 5169-78-8 YesY
ATC code R05DB24
PubChem CID 5484
ChemSpider 5284 YesY
UNII 2260ZP67IT YesY
KEGG D08604 YesY
Chemical data
Formula C15H17NS2 
Molecular mass 275.434 g/mol
 YesY (what is this?)  (verify)

Tipepidine was discovered in the 1950s.[1] Under the trade-names (Bithiodine, Sotal, Antupex, Asverin) is used as a centrally-acting cough suppressant of the opioid type. It is a member of the thiambutene series of open-chain (methadone-related) synthetic opioids, which include Ohton (dimethylthiambutene), a strong narcotic analgesic used particularly in veterinary medicine in Japan and other East Asian countries. It was developed in Japan in 1959 and is used as the citrate and hibenzate salts. The usual dose is 20 mg every 4–6 hours. Its relative weakness and other properties make it a drug which is not controlled in most countries or internationally.


  1. ^ ES Patent 272195