The album represents a wholly new direction for the singer. Her previous album, Prelude, a 'best of' album, had ended her classical career; Tissues and Issues is her first ever pop album.
The first single to be taken from the album, "Crazy Chick", released shortly before the album itself, reached number two on the UK Singles Chart. "Call My Name", the second single, reached number ten in October 2005. "Even God", the third single has debuted in the Top twenty in early December 2005. The fourth single, "Moodswings", was released on 27 February 2006, and peaked at number fourteen on the UK charts.
An early batch of the album had print errors on the right and left hand side title faces. The faces had the title "Charlotte Church : Crazy Chick", when it should have been "Charlotte Church : Tissues and Issues".
Tissues and Issues is Charlotte Church's second and final album with Sony Music UK.