|Group:||Group IV ((+)ssRNA)|
The Togaviridae are a family of viruses, including the following genera:
- Genus Alphavirus; type species: Sindbis virus, Eastern equine encephalitis virus, Western equine encephalitis virus, Venezuelan equine encephalitis virus, Ross River virus, O'nyong'nyong virus, Chikungunya, Semliki Forest virus
- Genus Rubivirus; type species: Rubella virus
The Togaviridae family belong to group IV of the Baltimore classification of viruses. The genome is linear, single-stranded, positive sense RNA that is 10,000–12,000 nucleotides long. The 5'-terminus carries a methylated nucleotide cap and the 3'-terminus has a polyadenylated tail, therefore resembling cellular mRNA. The virus is enveloped and forms spherical particles (65–70 nm diameter), the capsid within is icosahedral, constructed of 240 monomers, having a triangulation number of 4. The receptors for binding are unknown, however the tropism is varied and it is known that the glycoprotein spikes act as attachment proteins. After virus attachment and entry into the cell, gene expression and replication takes place within the cytoplasm. The vector for Togaviridæ is primarily the mosquito, where replication of the virus occurs.
The non-structural proteins are encoded at the 5’ end, formed during the first of two characteristic rounds of translation. These proteins are originally translated as a polyprotein, which consequently undergo self cleavage, forming four non-structural proteins responsible for gene expression and replication. The formation of a sub-genomic fragment, encoding the structural proteins and a negative sense fragment, a template for further synthesis of positive sense RNA are the characteristic second phase of translation. Assembly takes place at the cell surface, where the virus buds from the cell, acquiring the envelope. The replication cycle is very fast, taking around 4 hours.
Initially the Togavirus family included what are now called the Flaviviruses, within the Alphavirus genus. The Flaviviruses were formed into their own family when sufficient differences with the Alphaviruses were noted.
- Early 19th century—Rubella is identified as a distinct disease
- 1930—Western Equine Encephalitis virus is first isolated in the United States (the first alphavirus ever isolated)
- 1933—Eastern Equine Encephalitis virus is first isolated in the United States.
- 1938—Venezuelan Equine Encephalitis is isolated.
- 1941—Western Equine Encephalitis epidemic is seen in the United States. It affects 300,000 horses and 3,336 humans.
- 1941—Norman Gregg notices large number of children with cataracts following a rubella outbreak. This and other defects are then categorized under the congenital rubella syndrome.
- 1959—Ross River virus is isolated from Aedes vigilax mosquitoes (now known as Ochlerotatus vigilax) which were trapped at the Ross River in Australia.
- 1963—Ross River virus, which causes epidemic polyarthritis (mostly seen in Australia), is isolated by Doherty and colleagues.
- 1964—The last major epidemic of Rubella in the United States is seen. Approximately 20,000 infants are left with permanent damage following in-utero rubella exposure.
- 1969—Rubella vaccine is licensed
- 1972—The rubella vaccine is combined with the measles and mumps vaccines to form the Measles, Mumps and Rubella (MMR) vaccine.
- 1991–92—Most recent worldwide epidemic of rubella. Probably due to vaccine failures and missed vaccinations.
- 2005–2006—Large epidemic of the chikungunya virus on the island of La Réunion and the surrounding islands in the Indian Ocean.
- 2006—Major epidemic of the chikungunya virus in India with over 1.5 million cases reported.
- Stanford University
- Murray, et al., Medical Microbiology, 5th Edition, Philadelphia, Elsevier Mosby 2005 ISBN 0-323-03325-3
- "Aedes vigilax". NSW Arbovirus Surveillance & Vector Monitoring Program. The New South Wales Arbovirus Surveillance and Mosquito Monitoring Program. Retrieved 2010-06-05. "Note that 'Ochlerotatus vigilax' prior to 2000, was known as 'Aedes vigilax'"
- Doherty, R. L.; Carley, J. G.; Best, J. C. (1972). "Isolation of Ross River virus from man". The Medical journal of Australia 1 (21): 1083–1084. PMID 5040017.
- Meissner, H. C.; Reef, S. E.; Cochi, S. (2006). "Elimination of Rubella from the United States: A Milestone on the Road to Global Elimination". Pediatrics 117 (3): 933–935. doi:10.1542/peds.2005-1760. PMID 16510677.
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- Boughton, C. R.; Hawkes, R. A.; Naim, H. M. (1988). "Illness caused by a Barmah Forest-like virus in New South Wales". The Medical journal of Australia 148 (3): 146–147. PMID 2828896.
- Tsetsarkin, K.; Higgs, S.; McGee, C. E.; Lamballerie, X. D.; Charrel, R. N.; Vanlandingham, D. L. (2006). "Infectious Clones of Chikungunya Virus (La Réunion Isolate) for Vector Competence Studies". Vector-Borne and Zoonotic Diseases 6 (4): 325–337. doi:10.1089/vbz.2006.6.325. PMID 17187566.
- Lahariya, C.; Pradhan, S. K. (2006). "Emergence of chikungunya virus in Indian subcontinent after 32 years: A review". Journal of vector borne diseases 43 (4): 151–160. PMID 17175699.
- Togaviridae Genomes database search results from the Viral Bioinformatics Resource Center
- Viralzone: Togaviridae
- Virus Pathogen Database and Analysis Resource (ViPR): Togaviridae