Tolterodine

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Tolterodine
Tolterodine2DCSD.svg
Systematic (IUPAC) name
(R)-2-[3-(diisopropylamino)-1-phenylpropyl]-4-methylphenol
Clinical data
Trade names Detrol
AHFS/Drugs.com monograph
MedlinePlus a699026
Pregnancy cat.
Legal status
Pharmacokinetic data
Bioavailability 77%
Protein binding Approximately 96.3%.
Half-life 1.9-3.7 hours
Identifiers
CAS number 124937-51-5 YesY
ATC code G04BD07
PubChem CID 443879
DrugBank DB01036
ChemSpider 391967 YesY
UNII WHE7A56U7K YesY
KEGG D00646 YesY
ChEBI CHEBI:9622 YesY
ChEMBL CHEMBL1382 YesY
Chemical data
Formula C22H31NO 
Mol. mass 325.488 g/mol
 YesY (what is this?)  (verify)

Tolterodine (Detrol, Detrusitol) is an antimuscarinic drug that is used for symptomatic treatment of urinary incontinence.[1]

It is marketed by Pfizer in Canada and the United States by its brand name Detrol. In Egypt it is also found under the trade names Tolterodine by Sabaa and Incont L.A. by Adwia.

Use[edit]

Detrusor overactivity (DO, contraction of the muscular bladder wall) is the most common form of UI in older adults. It is characterized by uninhibited bladder contractions causing an uncontrollable urge to void. Urinary frequency, urge incontinence and nocturnal incontinence occur. Abnormal bladder contractions that coincide with the urge to void can be measured by urodynamic studies. Treatment is bladder retraining,[2] pelvic floor therapy or with drugs that inhibit bladder contractions such as oxybutinin and tolterodine.

Pharmacology[edit]

Tolterodine acts on M2 and M3 [3] subtypes of muscarinic receptors whereas older antimuscarinic treatments for overactive bladder act more specifically on M3 receptors. It is marketed and manufactured by Pfizer.

Tolterodine, although it acts on all types of receptors, has fewer side effects than oxybutynin (M3 and M1 selective, but more so in the parotid than in the bladder) as tolterodine targets the bladder more than other areas of the body. This means that less drug needs to be given daily (due to efficient targeting of the bladder) and so there are fewer side effects.[citation needed]

Side effects of tolterodine[edit]

Known side effects:

The following reactions have been reported in patients who have taken tolterodine since it has become available:

Contraindications:

Not to be used in patients with myasthenia gravis and angle closure glaucoma.

References[edit]

  1. ^ Philip Van Kerrebroeck, Karl Kreder, Udo Jonas, Norm Zinner, Alan Wein (2001). "Tolterodine once-daily: superior efficacy and tolerability in the treatment of the overactive bladder1". Urology 57 (3): 414–421. doi:10.1016/s0090-4295(00)01113-4. 
  2. ^ Bladder retraining ichelp.org Interstitial Cystitis Association Accessed July 13, 2012
  3. ^ [1]

External links[edit]