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On its launch, Toonami broadcast on Saturday evenings from 6:00 pm to 8:00 pm and on Sunday afternoons from 3:00 pm to 5:00 pm. Each day's programming was repeated in the Toonami "Late Run" from 11:00 pm to 1:00 am. Toonami soon expanded to weekdays, and for a number of years could be seen seven days a week. Although time-slots varied, the main Toonami block remained on weekday afternoons; in 2005 it was airing weeknights from 6.00pm, with mini-marathons playing on Saturday and Sunday mornings.
In September 2006, Toonami was dropped from the Cartoon Network schedule. Former Toonami programming, and new programming that would have previously gone to Toonami is now spread out across the network's other time-slots.