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Systematic (IUPAC) name
(8S,9S,10S,11S,13S,14S,16R,17S)-9-Fluoro-11- hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl- 7,8,11,12,14,15,16,17-octahydro-6H- cyclopenta[a]phenanthren-3-one
Clinical data
Trade names Topicort
AHFS/ monograph
MedlinePlus a605026
  • Prescription only
382-67-2 YesY
D07XC02 (combinations)
PubChem CID 5311067
DrugBank DB00547 YesY
ChemSpider 21117768 YesY
KEGG D03697 YesY
Chemical data
Formula C22H29FO4
376.462 g/mol
 N (what is this?)  (verify)

Desoximetasone is a medication belonging to the family of medications known as topical corticosteroids. It is used for the relief of various skin conditions, including rashes. It helps to reduce redness, itching, and irritation.[1] Desoximetasone is a synthetic corticosteroid, a class of primarily synthetic steroids used as anti-inflammatory and anti-pruritic agents.

Three brand name products are available (availability depending on country):

  • Topicort Emollient Cream (0.25% desoximetasone)
  • Topicort LP Emollient Cream (0.05% desoximetasone)
  • Topisolon Cream (0.25% desoximetasone)


When using desoximetasone, some of the medication may be absorbed through the skin and into the bloodstream. Too much absorption can lead to unwanted side effects elsewhere in the body. To keep this problem to a minimum, avoid using large amounts of desoximetasone over large areas, do not use it for extended periods of time, and do not cover it with airtight dressings such as plastic wrap or adhesive bandages unless specifically told to by your doctor.[1] Children may absorb more medication than adults do. Desoximetasone is for use only on the skin and should be kept out of the eyes.

Desoximetasone can also be used to treat some types of psoriasis.


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