Torasemide

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Torasemide
Torasemide.svg
Torasemide bas.png
Systematic (IUPAC) name
N-[(isopropylamino)carbonyl]-4-[(3-methylphenyl)amino]pyridine-3-sulfonamide
Clinical data
AHFS/Drugs.com International Drug Names
MedlinePlus a601212
Pregnancy cat. C (US)
Legal status -only (US)
Routes Oral, IV
Pharmacokinetic data
Bioavailability 80-90%
Protein binding Highly bound (>99%).
Metabolism Hepatic (80%)
Half-life 3.5 hours; Cirrhosis: 7-8 hours
Identifiers
CAS number 56211-40-6 YesY
ATC code C03CA04
PubChem CID 41781
DrugBank DB00214
ChemSpider 38123 YesY
UNII W31X2H97FB YesY
KEGG D00382 YesY
ChEBI CHEBI:9637 N
ChEMBL CHEMBL1148 YesY
Chemical data
Formula C16H20N4O3S 
Mol. mass 348.421 g/mol
 N (what is this?)  (verify)

Torasemide (rINN) or torsemide (USAN) is a pyridine-sulfonyl urea type loop diuretic mainly used in the management of edema associated with congestive heart failure. It is also used at low doses for the management of hypertension. It is marketed under the brand name Demadex, Diuver and Examide.

Compared to other loop diuretics, torasemide has a more prolonged diuretic effect than equipotent doses of furosemide and relatively decreased potassium-loss. There is no evidence of torasemide-induced ototoxicity demonstrated in humans.[1]

References[edit]

  1. ^ Dunn CJ, Fitton A, Brogden RN (January 1995). "Torasemide. An update of its pharmacological properties and therapeutic efficacy". Drugs 49 (1): 121–42. doi:10.2165/00003495-199549010-00009. PMID 7705212. 

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