Torasemide

Torasemide

Systematic (IUPAC) name
N-[(isopropylamino)carbonyl]-4-[(3-methylphenyl)amino]pyridine-3-sulfonamide
Clinical data
AHFS/Drugs.com	International Drug Names
MedlinePlus	a601212
Pregnancy cat.	C(US)
Legal status	℞-only (US)
Routes	Oral, IV
Pharmacokinetic data
Bioavailability	80-90%
Protein binding	Highly bound (>99%).
Metabolism	Hepatic (80%)
Half-life	3.5 hours; Cirrhosis: 7-8 hours
Identifiers
CAS number	56211-40-6
ATC code	C03CA04
PubChem	CID 41781
DrugBank	APRD00217
ChemSpider	38123 Y
UNII	W31X2H97FB Y
KEGG	D00382 Y
ChEMBL	CHEMBL1148 Y
Chemical data
Formula	C16H20N4O3S
Mol. mass	348.421 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C16H20N4O3S/c1-11(2)18-16(21)20-24(22,23)15-10-17-8-7-14(15)19-13-6-4-5-12(3)9-13/h4-11H,1-3H3,(H,17,19)(H2,18,20,21) Y Key:NGBFQHCMQULJNZ-UHFFFAOYSA-N Y
Y(what is this?)  (verify)

Torasemide (rINN) or torsemide (USAN) is a pyridine-sulfonyl urea type [loop diuretic]] mainly used in the management of edema associated with congestive heart failure. It is also used at low doses for the management of hypertension. It is marketed under the brand name Demadex and Diuver.

Compared to other loop diuretics, torasemide has a more prolonged diuretic effect than equipotent doses of furosemide and relatively decreased potassium-loss. There is no evidence of torasemide-induced ototoxicity demonstrated in humans.

External links

• Medlineplus drug information: Torsemide (Systemic) – information from USP DI Advice for the Patient