Touton giant cell

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Touton giant cells in a juvenile xanthogranuloma. H&E stain.

Touton giant cells are seen in lesions with high lipid content such as fat necrosis, xanthoma, and xanthogranulomas. They are also found in dermatofibroma.[1]

They are formed by the fusion of epithelioid cells (macrophages), and contain a ring of nuclei surrounded by a foamy cytoplasm.[2]

Touton giant cells are named for Karl Touton.[3]


  1. ^ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. pp. 14, 15. ISBN 1-4160-2999-0. 
  2. ^ Grant-Kels, Jane (2007). Color Atlas of Dermatopathology. City: Informa Healthcare. pp. 107, 119. ISBN 0-8493-3794-1. 
  3. ^ Aterman, K.; Remmele, W.; Smith, M. (Jun 1988). "Karl Touton and his "xanthelasmatic giant cell." A selective review of multinucleated giant cells". The American Journal of dermatopathology 10 (3): 257–269. ISSN 0193-1091. PMID 3068999.  edit

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