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Toxicology testing, also known as safety testing, or toxicity testing, is conducted to determine the degree to which a substance can damage a living or non-living organisms. It is often conducted by researchers to comply with governing regulations. Some toxicology testing is chemical testing while some others use animals in the laboratory studies. Contract animal testing facilities such as Huntingdon Life Sciences and Inveresk Research International conduct a variety of tests on behalf of customers, including the manufacturer of medicines and household products.
Toxicity tests examine finished products such as pesticides, medications, food additives such as artificial sweeteners, packing materials, and air freshener, or their chemical ingredients. The substances are applied to the skin or eyes; injected intravenously, intramuscularly, or subcutaneously; inhaled either by placing a mask over the animals and restraining them, or by placing them in an inhalation chamber; or administered orally, through a tube into the stomach, or placing them in the animals' food. Doses may be given once, repeated regularly for many months, or for the lifespan of the animal.
A contract research organization (CRO) is an organization that provides support to the pharmaceutical, biotechnology, chemical, and medical device industries in the form of research services outsourced on a contract basis. A CRO may provide toxicity testing services, along with others such as assay development, preclinical research, clinical research, clinical trials management, and pharmacovigilance. CROs also support foundations, research institutions, and universities, in addition to governmental organizations (such as the NIH, EMEA, etc.).