This article may be expanded with text translated from the corresponding article in German. (December 2013) Click [show] for important translation instructions.
View a machine-translated version of the German article.
Google's machine translation is a useful starting point for translations, but translators must revise errors as necessary and confirm that the translation is accurate, rather than simply copy-pasting machine-translated text into the English Wikipedia.
Do not translate text that appears unreliable or low-quality. If possible, verify the text with references provided in the foreign-language article.
Trametes versicolor – also known as Coriolus versicolor and Polyporus versicolor – is a common polyporemushroom found throughout the world. Meaning 'of several colours', versicolor reliably describes this mushroom found in different colors. By example, due to its resembling multiple colors in the tail of wild turkey, T. versicolor is commonly called turkey tail.
The top surface of the cap shows typical concentric zones of different colours. The flesh is 1–3 mm thick and has leathery texture. Older specimens, such as the one pictured, can have zones with green algae growing on them, thus appearing green. It commonly grows in tiled layers. The cap is rust-brown or darker brown, sometimes with blackish zones. The cap is flat, up to 8 x 5 x 0.5-1 cm in area. It is often triangular or round, with zones of fine hairs. The pore surface is whitish to light brown, pores round and with age twisted and labyrinthine. 2-5 pores per millimeter
According to the American Cancer Society: "Available scientific evidence does not support claims that the raw mushroom itself is an effective anti-cancer agent in humans. But there is some scientific evidence that substances derived from parts of the mushroom may be useful against cancer."
Polysaccharide-K (PSK) displays anticancer activity in preliminary laboratory assessments in vitro,in vivo and in preliminary human research. Other basic research showed that PSK might reduce mutagen-induced, radiation-induced and spontaneously induced development of experimental cancer cell preparations. PSK is beneficial as an adjuvant in the treatment of gastric, esophageal, colorectal, breast and lung cancers. Human pilot studies indicate PSK adjuvants might reduce cancer recurrence. Other basic research demonstrated that the mushroom inhibited certain human cancer cell lines in vitro. Further in vitro studies showed that a nutraceutical blend (MC-S) of PSK, lentinan and other fungal extracts might inhibit cancer cell proliferation under laboratory conditions.
The MD Anderson Cancer Center reported that it is a "promising candidate for chemoprevention due to the multiple effects on the malignant process, limited side effects and safety of daily oral doses for extended periods of time." At present, however, no approved drugs, mechanisms of action or scientifically verified anti-disease activities stem from this mushroom.
^Jiménez-Medina E, Berruguilla E, Romero I et al. (2008), "The immunomodulator PSK induces in vitro cytotoxic activity in tumour cell lines via arrest of cell cycle and induction of apoptosis", BMC Cancer8: 78, doi:10.1186/1471-2407-8-78, PMC2291471, PMID18366723.CS1 maint: Explicit use of et al. (link)
^Yamasaki A, Shoda M, Iijima H et al. (March 2009), "A protein-bound polysaccharide, PSK, enhances tumor suppression induced by docetaxel in a gastric cancer xenograft model", Anticancer Res.29 (3): 843–50, PMID19414318.CS1 maint: Explicit use of et al. (link)
^ abOba K, Teramukai S, Kobayashi M, Matsui T, Kodera Y, Sakamoto J (June 2007), "Efficacy of adjuvant immunochemotherapy with polysaccharide K for patients with curative resections of gastric cancer", Cancer Immunol. Immunother.56 (6): 905–11, doi:10.1007/s00262-006-0248-1, PMID17106715.
^"Antimetastatic effects of PSK (Krestin), a protein-bound polysaccharide obtained from basidiomycetes: an overview". Cancer Epidemiol. Biomarkers Prev.4 (3): 275–81. 1995. PMID7606203.
^Fisher, M. Y.; Yang, L. X. (May 2002). "Anticancer effects and mechanisms of polysaccharide-K (PSK): implications of cancer immunotherapy". Anticancer research22 (3): 1737–1754. ISSN0250-7005. PMID12168863.edit
^Sugimachi K, Maehara Y, Ogawa M, Kakegawa T, Tomita M (4 August 1997), "Dose intensity of uracil and tegafur in postoperative chemotherapy for patients with poorly differentiated gastric cancer", Cancer Chemother Pharmacol40 (3): 233–8, doi:10.1007/s002800050652, PMID9219507
^Hsieh TC, Wu JM (January 2001), "Cell growth and gene modulatory activities of Yunzhi (Windsor Wunxi) from mushroom Trametes versicolor in androgen-dependent and androgen-insensitive human prostate cancer cells", Int J Oncol18 (1): 81–8, doi:10.3892/ijo.18.1.81, PMID11115542
^Dong Y, Yang MM, Kwan CY (1 January 1997), "In vitro inhibition of proliferation of HL-60 cells by tetrandrine and coriolus versicolor peptide derived from Chinese medicinal herbs", Life Sci60 (8): 135–40, doi:10.1016/S0024-3205(96)00695-9, PMID9042394