Transcription elongation regulator 1

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Transcription elongation regulator 1
Protein TCERG1 PDB 1e0l.png
PDB rendering based on 1e0l.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols TCERG1 ; CA150; TAF2S; Urn1
External IDs OMIM605409 MGI1926421 HomoloGene4879 GeneCards: TCERG1 Gene
RNA expression pattern
PBB GE TCERG1 202396 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 10915 56070
Ensembl ENSG00000113649 ENSMUSG00000024498
UniProt O14776 Q8CGF7
RefSeq (mRNA) NM_001040006 NM_001039474
RefSeq (protein) NP_001035095 NP_001034563
Location (UCSC) Chr 5:
145.83 – 145.89 Mb
Chr 18:
42.51 – 42.58 Mb
PubMed search [1] [2]

Transcription elongation regulator 1, also known as TCERG1, is a protein which in humans is encoded by the TCERG1 gene.[1][2][3]

Function[edit]

This gene encodes a nuclear protein that regulates transcriptional elongation and pre-mRNA splicing. The encoded protein interacts with the hyperphosphorylated C-terminal domain of RNA polymerase II via multiple FF domains, and with the pre-mRNA splicing factor SF1 via a WW domain. Alternative splicing results in multiple transcripts variants encoding different isoforms.[1]

Interactions[edit]

Transcription elongation regulator 1 has been shown to interact with SF1[4] and POLR2A.[5]

References[edit]

  1. ^ a b "Entrez Gene: TCERG1 transcription elongation regulator 1". 
  2. ^ Suñé C, Hayashi T, Liu Y, Lane WS, Young RA, Garcia-Blanco MA (October 1997). "CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription". Molecular and Cellular Biology 17 (10): 6029–39. PMC 232452. PMID 9315662. 
  3. ^ Bohne J, Cole SE, Suñe C, Lindman BR, Ko VD, Vogt TF, Garcia-Blanco MA (October 2000). "Expression analysis and mapping of the mouse and human transcriptional regulator CA150". Mammalian Genome : Official Journal of the International Mammalian Genome Society 11 (10): 930–3. doi:10.1007/s003350010162. PMID 11003711. 
  4. ^ Goldstrohm, A C; Albrecht T R, Suñé C, Bedford M T, Garcia-Blanco M A (November 2001). "The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1". Mol. Cell. Biol. (United States) 21 (22): 7617–28. doi:10.1128/MCB.21.22.7617-7628.2001. ISSN 0270-7306. PMC 99933. PMID 11604498. 
  5. ^ Carty, S M; Goldstrohm A C, Suñé C, Garcia-Blanco M A, Greenleaf A L (August 2000). "Protein-interaction modules that organize nuclear function: FF domains of CA150 bind the phosphoCTD of RNA polymerase II". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (16): 9015–20. doi:10.1073/pnas.160266597. ISSN 0027-8424. PMC 16813. PMID 10908677. 

Further reading[edit]