Transcription elongation regulator 1

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Transcription elongation regulator 1
Protein TCERG1 PDB 1e0l.png
PDB rendering based on 1e0l.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols TCERG1 ; CA150; TAF2S; Urn1
External IDs OMIM605409 MGI1926421 HomoloGene4879 GeneCards: TCERG1 Gene
RNA expression pattern
PBB GE TCERG1 202396 at tn.png
More reference expression data
Species Human Mouse
Entrez 10915 56070
Ensembl ENSG00000113649 ENSMUSG00000024498
UniProt O14776 Q8CGF7
RefSeq (mRNA) NM_001040006 NM_001039474
RefSeq (protein) NP_001035095 NP_001034563
Location (UCSC) Chr 5:
145.83 – 145.89 Mb
Chr 18:
42.51 – 42.58 Mb
PubMed search [1] [2]

Transcription elongation regulator 1, also known as TCERG1, is a protein which in humans is encoded by the TCERG1 gene.[1][2][3]


This gene encodes a nuclear protein that regulates transcriptional elongation and pre-mRNA splicing. The encoded protein interacts with the hyperphosphorylated C-terminal domain of RNA polymerase II via multiple FF domains, and with the pre-mRNA splicing factor SF1 via a WW domain. Alternative splicing results in multiple transcripts variants encoding different isoforms.[1]


Transcription elongation regulator 1 has been shown to interact with SF1[4] and POLR2A.[5]


  1. ^ a b "Entrez Gene: TCERG1 transcription elongation regulator 1". 
  2. ^ Suñé C, Hayashi T, Liu Y, Lane WS, Young RA, Garcia-Blanco MA (October 1997). "CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription". Molecular and Cellular Biology 17 (10): 6029–39. PMC 232452. PMID 9315662. 
  3. ^ Bohne J, Cole SE, Suñe C, Lindman BR, Ko VD, Vogt TF, Garcia-Blanco MA (October 2000). "Expression analysis and mapping of the mouse and human transcriptional regulator CA150". Mammalian Genome : Official Journal of the International Mammalian Genome Society 11 (10): 930–3. doi:10.1007/s003350010162. PMID 11003711. 
  4. ^ Goldstrohm, A C; Albrecht T R; Suñé C; Bedford M T; Garcia-Blanco M A (November 2001). "The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1". Mol. Cell. Biol. (United States) 21 (22): 7617–28. doi:10.1128/MCB.21.22.7617-7628.2001. ISSN 0270-7306. PMC 99933. PMID 11604498. 
  5. ^ Carty, S M; Goldstrohm A C; Suñé C; Garcia-Blanco M A; Greenleaf A L (August 2000). "Protein-interaction modules that organize nuclear function: FF domains of CA150 bind the phosphoCTD of RNA polymerase II". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (16): 9015–20. doi:10.1073/pnas.160266597. ISSN 0027-8424. PMC 16813. PMID 10908677. 

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