Transcription initiation protein SPT3 homolog

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Suppressor of Ty 3 homolog (S. cerevisiae)
Symbols SUPT3H ; SPT3; SPT3L
External IDs OMIM602947 MGI1923723 HomoloGene121570 GeneCards: SUPT3H Gene
RNA expression pattern
PBB GE SUPT3H 206506 s at tn.png
PBB GE SUPT3H 211106 at tn.png
More reference expression data
Species Human Mouse
Entrez 8464 109115
Ensembl ENSG00000196284 ENSMUSG00000038954
UniProt O75486 Q8BVY4
RefSeq (mRNA) NM_001261823 NM_178652
RefSeq (protein) NP_001248752 NP_848767
Location (UCSC) Chr 6:
44.78 – 45.35 Mb
Chr 17:
44.78 – 45.12 Mb
PubMed search [1] [2]

Transcription initiation protein SPT3 homolog is a protein that in humans is encoded by the SUPT3H gene.[1][2][3]


Transcription initiation protein SPT3 homolog has been shown to interact with GCN5L2,[4][5] TAF6L,[5] TADA3L,[5] TAF5L,[5] SF3B3,[5] SUPT7L,[5] Myc,[6] TAF9,[5] Transformation/transcription domain-associated protein,[5] TAF12,[5] TAF10,[4][5] TAF4[4] and DDB1.[5]


  1. ^ Ogryzko VV, Kotani T, Zhang X, Schiltz RL, Howard T, Yang XJ, Howard BH, Qin J, Nakatani Y (August 1998). "Histone-like TAFs within the PCAF histone acetylase complex". Cell 94 (1): 35–44. doi:10.1016/S0092-8674(00)81219-2. PMID 9674425. 
  2. ^ Martinez E, Kundu TK, Fu J, Roeder RG (October 1998). "A human SPT3-TAFII31-GCN5-L acetylase complex distinct from transcription factor IID". J Biol Chem 273 (37): 23781–5. doi:10.1074/jbc.273.37.23781. PMID 9726987. 
  3. ^ "Entrez Gene: SUPT3H suppressor of Ty 3 homolog (S. cerevisiae)". 
  4. ^ a b c Brand, M; Moggs J G; Oulad-Abdelghani M; Lejeune F; Dilworth F J; Stevenin J; Almouzni G; Tora L (June 2001). "UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation". EMBO J. (England) 20 (12): 3187–96. doi:10.1093/emboj/20.12.3187. ISSN 0261-4189. PMC 150203. PMID 11406595. 
  5. ^ a b c d e f g h i j k Martinez, E; Palhan V B; Tjernberg A; Lymar E S; Gamper A M; Kundu T K; Chait B T; Roeder R G (October 2001). "Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo". Mol. Cell. Biol. (United States) 21 (20): 6782–95. doi:10.1128/MCB.21.20.6782-6795.2001. ISSN 0270-7306. PMC 99856. PMID 11564863. 
  6. ^ Liu, Xiaohui; Tesfai Jerusalem; Evrard Yvonne A; Dent Sharon Y R; Martinez Ernest (May 2003). "c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation". J. Biol. Chem. (United States) 278 (22): 20405–12. doi:10.1074/jbc.M211795200. ISSN 0021-9258. PMC 4031917. PMID 12660246. 

Further reading[edit]