Transferrin receptor
| Identifiers | |
|---|---|
| Symbol | TFRC |
| Alt. symbols | CD71, TFR1 |
| Entrez | 7037 |
| HUGO | 11763 |
| OMIM | 190010 |
| RefSeq | NM_003234 |
| UniProt | P02786 |
| Other data | |
| Locus | Chr. 3 q29 |
| Identifiers | |
|---|---|
| Symbol | TFR2 |
| Alt. symbols | HFE3, TFRC2 |
| Entrez | 7036 |
| HUGO | 11762 |
| OMIM | 604720 |
| RefSeq | NM_003227 |
| UniProt | Q9UP52 |
| Other data | |
| Locus | Chr. 7 q22 |
Transferrin receptor (TfR) is a carrier protein for transferrin. It is needed for the import of iron into the cell and is regulated in response to intracellular iron concentration. It imports iron by internalizing the transferrin-iron complex through receptor-mediated endocytosis.[1]
Contents |
[edit] Regulation
Low iron concentrations promote increased levels of transferrin receptor, to increase iron intake into the cell. Thus, transferrin receptor maintains cellular iron homeostasis.
TfR production in the cell is regulated according to iron levels by iron response/regulatory element binding protein (IRE-BP), also referred to as Iron Regulatory Protein (IRP). This protein binds to the hairpin like structure (IRE) that is in the 3' UTR of the TfR receptor. Once binding occurs, degradation of mRNA of IRE is inhibited.
[edit] See also
[edit] References
- ^ Qian ZM, Li H, Sun H, Ho K (December 2002). "Targeted drug delivery via the transferrin receptor-mediated endocytosis pathway". Pharmacol. Rev. 54 (4): 561–87. doi:10.1124/pr.54.4.561. PMID 12429868.; Figure 3: The cycle of transferrin and transferrin receptor 1-mediated cellular iron uptake.
[edit] Further reading
- Testa U, Kühn L, Petrini M, Quaranta MT, Pelosi E, Peschle C (July 1991). "Differential regulation of iron regulatory element-binding protein(s) in cell extracts of activated lymphocytes versus monocytes-macrophages". J. Biol. Chem. 266 (21): 13925–30. PMID 1856222.
- Daniels TR, Delgado T, Rodriguez JA, Helguera G, Penichet ML (November 2006). "The transferrin receptor part I: Biology and targeting with cytotoxic antibodies for the treatment of cancer". Clin. Immunol. 121 (2): 144–58. doi:10.1016/j.clim.2006.06.010. PMID 16904380.; Figure 3: Cellular uptake of iron through the Tf system via receptor-mediated endocytosis.
- Daniels TR, Delgado T, Helguera G, Penichet ML (November 2006). "The transferrin receptor part II: targeted delivery of therapeutic agents into cancer cells". Clin. Immunol. 121 (2): 159–76. doi:10.1016/j.clim.2006.06.006. PMID 16920030.
[edit] External links
- MeSH Transferrin+receptor
- Okam M (2001-01-29). "Transerrin and Iron Transport Physiology". Information Center for Sickle Cell and Thalassemic Disorders. Brigham and Women's Hospital and Harvard Medical School. http://sickle.bwh.harvard.edu/iron_transport.html. Retrieved 2010-12-19.
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