Transforming growth factor, beta 3

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Transforming growth factor, beta 3
Protein TGFB3 PDB 1ktz.png
PDB rendering based on 1ktz.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols TGFB3 ; ARVD; ARVD1; RNHF; TGF-beta3
External IDs OMIM190230 MGI98727 HomoloGene2433 GeneCards: TGFB3 Gene
RNA expression pattern
PBB GE TGFB3 209747 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7043 21809
Ensembl ENSG00000119699 ENSMUSG00000021253
UniProt P10600 P17125
RefSeq (mRNA) NM_003239 NM_009368
RefSeq (protein) NP_003230 NP_033394
Location (UCSC) Chr 14:
76.42 – 76.45 Mb
Chr 12:
86.06 – 86.08 Mb
PubMed search [1] [2]

Transforming growth factor beta-3 is a protein that in humans is encoded by the TGFB3 gene.[1][2]


Interactions[edit]

Transforming growth factor, beta 3 has been shown to interact with TGF beta receptor 2.[3][4][5][6]

References[edit]

  1. ^ Bandyopadhyay B, Fan J, Guan S, Li Y, Chen M, Woodley DT, Li W (March 2006). "A "traffic control" role for TGFbeta3: orchestrating dermal and epidermal cell motility during wound healing". J Cell Biol 172 (7): 1093–105. doi:10.1083/jcb.200507111. PMC 2063766. PMID 16549496. 
  2. ^ "Entrez Gene: TGFB3 transforming growth factor, beta 3". 
  3. ^ De Crescenzo, Gregory; Pham Phuong L, Durocher Yves, O'Connor-McCourt Maureen D (May 2003). "Transforming growth factor-beta (TGF-beta) binding to the extracellular domain of the type II TGF-beta receptor: receptor capture on a biosensor surface using a new coiled-coil capture system demonstrates that avidity contributes significantly to high affinity binding". J. Mol. Biol. (England) 328 (5): 1173–83. doi:10.1016/S0022-2836(03)00360-7. ISSN 0022-2836. PMID 12729750. 
  4. ^ Hart, P John; Deep Shashank; Taylor Alexander B; Shu Zhanyong; Hinck Cynthia S; Hinck Andrew P (March 2002). "Crystal structure of the human TbetaR2 ectodomain--TGF-beta3 complex". Nat. Struct. Biol. (United States) 9 (3): 203–8. doi:10.1038/nsb766. ISSN 1072-8368. PMID 11850637. 
  5. ^ Barbara, N P; Wrana J L; Letarte M (January 1999). "Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily". J. Biol. Chem. (UNITED STATES) 274 (2): 584–94. doi:10.1074/jbc.274.2.584. ISSN 0021-9258. PMID 9872992. 
  6. ^ Rotzer, D; Roth M; Lutz M; Lindemann D; Sebald W; Knaus P (February 2001). "Type III TGF-beta receptor-independent signalling of TGF-beta2 via TbetaRII-B, an alternatively spliced TGF-beta type II receptor". EMBO J. (England) 20 (3): 480–90. doi:10.1093/emboj/20.3.480. ISSN 0261-4189. PMC 133482. PMID 11157754. 

External links[edit]

Further reading[edit]