Transforming growth factor, beta 3

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Transforming growth factor, beta 3
Protein TGFB3 PDB 1ktz.png
PDB rendering based on 1ktz.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols TGFB3 ; ARVD; ARVD1; RNHF; TGF-beta3
External IDs OMIM190230 MGI98727 HomoloGene2433 GeneCards: TGFB3 Gene
RNA expression pattern
PBB GE TGFB3 209747 at tn.png
More reference expression data
Species Human Mouse
Entrez 7043 21809
Ensembl ENSG00000119699 ENSMUSG00000021253
UniProt P10600 P17125
RefSeq (mRNA) NM_003239 NM_009368
RefSeq (protein) NP_003230 NP_033394
Location (UCSC) Chr 14:
76.42 – 76.45 Mb
Chr 12:
86.06 – 86.08 Mb
PubMed search [1] [2]

Transforming growth factor beta-3 is a protein that in humans is encoded by the TGFB3 gene.[1][2]


Transforming growth factor, beta 3 has been shown to interact with TGF beta receptor 2.[3][4][5][6]


  1. ^ Bandyopadhyay B, Fan J, Guan S, Li Y, Chen M, Woodley DT, Li W (March 2006). "A "traffic control" role for TGFbeta3: orchestrating dermal and epidermal cell motility during wound healing". J Cell Biol 172 (7): 1093–105. doi:10.1083/jcb.200507111. PMC 2063766. PMID 16549496. 
  2. ^ "Entrez Gene: TGFB3 transforming growth factor, beta 3". 
  3. ^ De Crescenzo, Gregory; Pham Phuong L, Durocher Yves, O'Connor-McCourt Maureen D (May 2003). "Transforming growth factor-beta (TGF-beta) binding to the extracellular domain of the type II TGF-beta receptor: receptor capture on a biosensor surface using a new coiled-coil capture system demonstrates that avidity contributes significantly to high affinity binding". J. Mol. Biol. (England) 328 (5): 1173–83. doi:10.1016/S0022-2836(03)00360-7. ISSN 0022-2836. PMID 12729750. 
  4. ^ Hart, P John; Deep Shashank; Taylor Alexander B; Shu Zhanyong; Hinck Cynthia S; Hinck Andrew P (March 2002). "Crystal structure of the human TbetaR2 ectodomain--TGF-beta3 complex". Nat. Struct. Biol. (United States) 9 (3): 203–8. doi:10.1038/nsb766. ISSN 1072-8368. PMID 11850637. 
  5. ^ Barbara, N P; Wrana J L; Letarte M (January 1999). "Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily". J. Biol. Chem. (UNITED STATES) 274 (2): 584–94. doi:10.1074/jbc.274.2.584. ISSN 0021-9258. PMID 9872992. 
  6. ^ Rotzer, D; Roth M; Lutz M; Lindemann D; Sebald W; Knaus P (February 2001). "Type III TGF-beta receptor-independent signalling of TGF-beta2 via TbetaRII-B, an alternatively spliced TGF-beta type II receptor". EMBO J. (England) 20 (3): 480–90. doi:10.1093/emboj/20.3.480. ISSN 0261-4189. PMC 133482. PMID 11157754. 

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