Transfusion hemosiderosis

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Transfusion hemosiderosis
Classification and external resources
ICD-10 T80.8
ICD-9 999.8

Transfusional hemosiderosis is the accumulation of iron in the liver and/or heart but also endocrine organs, in patients who receive frequent blood transfusions (such as those with thalassemia, sickle cell disease, aplastic anemia or myelodysplastic syndrome).

Treatment[edit]

Treatment is by chelation therapy with iron chelating agents such as deferoxamine, deferiprone or deferasirox.[1] If iron overload has caused end-organ damage, this is generally irreversible and may require transplantation.

Notable patients[edit]

Ted DeVita died of transfusional iron overload from too many blood transfusions.

See also[edit]

References[edit]

  1. ^ Hider, Robert C.; Kong, Xiaole (2013). "Chapter 8. Iron: Effect of Overload and Deficiency". In Astrid Sigel, Helmut Sigel and Roland K. O. Sigel. Interrelations between Essential Metal Ions and Human Diseases. Metal Ions in Life Sciences 13. Springer. pp. 229–294. doi:10.1007/978-94-007-7500-8_8. 

2. Lu JP, Hayashi K. Selective iron deposition in pancreatic islet B cells of transfusional iron-overloaded autopsy cases. Pathol Int. 1994 Mar;44(3):194-9.PubMed PMID: 8025661.