Traumatic acid

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Traumatic acid[1]
Traumatic acid structure.png
Identifiers
CAS number 6402-36-4 YesY
PubChem 5283028
ChEMBL CHEMBL470062 N
Jmol-3D images Image 1
Properties
Molecular formula C12H20O4
Molar mass 228.28
Melting point 166−167 °C
Boiling point 150−160 °C at 0.001 mmHg
Solubility in water Sparingly soluble
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N (verify) (what is: YesY/N?)
Infobox references

Traumatic acid is a monounsaturated dicarboxylic acid naturally occurring in plants. The compound was first isolated from wounded bean plants by American chemists James English Jr. and James Frederick Bonner and Dutch scientist Arie Jan Haagen-Smit in 1939.[2] Traumatic acid is a potent wound healing agent in plants ("wound hormone") that stimulates cell division near a trauma site to form a protective callus and to heal the damaged tissue. It may also act as a growth hormone, especially in inferior plants (e.g. algae). Traumatic acid is biosynthesized in plants by non-enzymatic oxidation of traumatin (12-oxo-trans-10-dodecenoic acid), another wound hormone.

At normal conditions, traumatic acid is a solid, crystalline, water insoluble substance.

Traumatic acid is used as an intermediate in prostaglandin synthesis. It is also a constituent of some pharmaceutical products, such as the odontostomatologic gel Restomyl, due to its mucosal re-epithelialization activity.

References[edit]

  1. ^ Merck Index, 11th Edition, 9493
  2. ^ English J Jr., Bonner J, Haagen-Smit AJ: Structure and synthesis of a plant wound hormone. Science 90:329. (1939)