On the morning of August 5, 1987 a Piedmont AirlinesBoeing 737-200 on a regularly scheduled flight struck deer after reaching V1 during the takeoff roll. One engine sustained damage and subsequently flamed out, and the aircraft immediately returned to the airport.
On June 16, 1994, a Fokker F28-4000 operated by USAir suffered a hard landing after which the right main landing gear collapsed. The jet slid to a stop causing significant damage to the aircraft and the runway. There were minor injuries during the landing and evacuation. The aircraft was repaired after several weeks at Tri-State and re-entered service later that year.
On January 8, 2003, Air Midwest Flight 5481 operating as US Airways Express Flight 5481 (N233YV), crashed at Charlotte-Douglas International Airport, killing all 21 aboard. It was determined that the accident was caused primarily by the faulty adjustment of an elevator cable - work that was performed just 2 days earlier at a facility at Tri-State Airport - by a mechanic that had never worked on that type of aircraft.
On August 17, 2006, Rima Qayyum, a woman of Pakistani origin residing within the US, was prevented from boarding a plane when it was found she had banned materials in her hand luggage. While these initially tested positive for explosive residue, subsequent analysis revealed that the liquids were harmless. Later testing revealed that it was just water and soap  The woman had purchased a one-way ticket on a flight to Charlotte, North Carolina. In 2008, Qayyum filed a federal lawsuit against US Airways for violating her civil rights.
On January 30, 2009, a Piper PA-34-200T Seneca crashed in the vicinity of KHTS during a significant snow event. The pilot was attempting to divert to KHTS due to a fuel emergency. All six aboard were killed.