Triamcinolone

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Triamcinolone
Systematic (IUPAC) name
(11β,16α)-9-fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
Identifiers
CAS number	124-94-7
ATC code	A01AC01 D07AB09, D07XB02, H02AB08, R01AD11, R03BA06, S01BA05
PubChem	31307
DrugBank	APRD00422
ChemSpider	29046
Chemical data
Formula	C21H27FO6
Mol. mass	394.434 g/mol
SMILES	eMolecules & PubChem
Synonyms	(8S,9R,10S,11S,13S,14S,16R,17S)-9-fluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one; (1R,2S,10S,11S,13R,14S,15S,17S)-1-fluoro-13,14,17-trihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-dien-5-one
Pharmacokinetic data
Bioavailability	?
Protein binding	68%
Metabolism	Hepatic
Half life	88 minutes
Excretion	Fecal and renal
Therapeutic considerations
Pregnancy cat.	A (Au), C (US)
Legal status	POM(UK) ℞-only(US)
Routes	Oral, topical, IM, intra-articular, intrasynovial

Triamcinolone (trade names Kenalog, Aristocort, Nasacort, Tri-Nasal, Triderm, Azmacort, Trilone, Volon A, Tristoject, Fougera, Tricortone,Triesence;) is a synthetic corticosteroid given orally, by injection, inhalation, or as a topical ointment or cream.

[edit] Uses

Triamcinolone is used in the post-operative period of certain cosmetic surgery procedures, notably rhinoplasty. Injected into the subcutaneous area, it may help to alleviate stubborn swelling, inflamed sebaceous cysts, and scar tissue.

Triamcinolone is occasionally used to treat severe cases of hayfever.^[1] Cream forms are used to treat keratosis pilaris, psoriasis, oral irritation after dental procedures. It is highly effective in the most severe cases of eczema, but may require a waiting period before subsequent treatments.Triamcinolone also used in case of severe arthritis, Lumbago sciatica. Injection is given to intra articular space of knee joing and also at the tip of the coccyx etc.^{[citation needed]} The drug may also be used to treat diabetic retinopathy.^[2]

[edit] Forms

Different triamcinolone salts are available, including acetonide, benetonide, furetonide, hexacetonide and diacetate.

Triamcinolone acetonide is a more potent type of triamcinolone, being about 8 times as effective as prednisone.

[edit] Side effects

Side effects of Triamcinolone include a sore throat, nosebleeds, increased coughing, headache, and runny nose. White patches in the throat or nose indicates a serious side effect. Symptoms of an allergic reaction include rash, itch, swelling, severe dizziness, trouble breathing.^[3]

An additional side effect for women is a prolonged menstrual cycle.

[edit] References

Box and vial of Kenalog intra-articular/intramuscular

1. ^ Hayfever (allergic rhinitis) - BUPA
2. ^ Gómez-Ulla F, Marticorena J, Alfaro DV 3rd, Fernández M, Méndez ER, Rothen M. (2006). "Intravitreal triamcinolone for the treatment of diabetic macular edema.". Curr Diabetes Rev. 2 (1): 99-112. PMID 18220620. 
3. ^ "Drugs and Treatments - Nasacort AQ Nasl - Patient Handout". WebMD. http://www.webmd.com/drugs/drug-16244-Nasacort+AQ.aspx?drugid=16244&drugname=Nasacort%20AQ. Retrieved on 2008-03-24. 

[edit] External links

• MedlinePlus DrugInfo medmaster-a601124

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