Triamcinolone

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Triamcinolone
Triamcinolone structure.png
Triamcinolone ball-and-stick animation.gif
Systematic (IUPAC) name
(11β,16α)-9-fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
Clinical data
Trade names Kenalog Nasacort
AHFS/Drugs.com monograph
Pregnancy cat. A (AU) C (US)
Legal status POM (UK) -only (US)
Routes Oral, topical, IM, intra-articular, intrasynovial
Pharmacokinetic data
Protein binding 68%
Metabolism Hepatic
Half-life 88 minutes
Excretion Fecal and renal
Identifiers
CAS number 124-94-7 YesY
ATC code A01AC01 C05AA12, D07AB09, H02AB08, R01AD11, R03BA06, S01BA05
PubChem CID 31307
IUPHAR ligand 2870
DrugBank DB00620
ChemSpider 29046 YesY
UNII 1ZK20VI6TY YesY
KEGG D00385 YesY
ChEBI CHEBI:9667 N
ChEMBL CHEMBL1451 YesY
Synonyms
Chemical data
Formula C21H27FO6 
Mol. mass 394.434 g/mol
 N (what is this?)  (verify)

Triamcinolone is a long-acting synthetic corticosteroid given orally, by injection, by inhalation, or as a topical ointment or cream.

Uses[edit]

Triamcinolone is used to treat several different medical conditions, such as eczema, psoriasis, arthritis, allergies, ulcerative colitis, lupus, sympathetic ophthalmia, temporal arteritis, uveitis, ocular inflammation, Urushiol-induced contact dermatitis, visualization during vitrectomy and the prevention of asthma attacks. It will not treat an asthma attack once it has already begun.[1][2][3] It has also been used off-label for macular degeneration.[4]

Prior to 2007 it was manufactured under the name Azmacort as a corticosteroid inhaler for asthma long-term care. The patent holder, Sanofi, sold it under the brand name Nasacort.

In 2010, TEVA and Perrigo launched the first generic inhalable triamcinolone.[5]

Triamcinolone is used to alleviate infection-induced eczema in fungal skin infections in the combination drug of econazole/triamcinolone.

Triamcinolone acetonide is one of the ingredients of Ledermix - an endodontic (tooth's root canal) lotion used between sessions.

Forms[edit]

Different triamcinolone derivatives are available, including acetonide, benetonide, furetonide, hexacetonide and diacetate.

Triamcinolone acetonide is a more potent type of triamcinolone, being about eight times as effective as prednisone.

Side effects[edit]

Side effects of triamcinolone include sore throat, nosebleeds, increased coughing, headache, and runny nose.[citation needed] White patches in the throat or nose indicate a serious side effect. Symptoms of an allergic reaction include rash, itch, swelling, severe dizziness, trouble breathing.[6] An additional side effect for women is a prolonged menstrual cycle.

Trade names[edit]

Trade names for triamcinolone include Aristocort, Kenacort, Kenalog, Tricort, Triaderm, Azmacort, Trilone, Volon A, Tristoject, Tricortone and Ratio-Triacomb.

See also[edit]

References[edit]

Aristocort (triamcinolone) topical cream
Kenalog (triamcinolone) IM injection
  1. ^ Triamcinolone - Drugs.com
  2. ^ Triamcinolone Inhalation - Drugs.com
  3. ^ Alcon Receives FDA Approval of Triesence Injectable Triamcinolone Suspension for Use in Eye Surgery - Drugs.com
  4. ^ Age-Related Macular Degeneration (AMD) Treatment
  5. ^ Perrigo Announces Launch Of Generic Version Of Nasacort AQ - CBS Detroit
  6. ^ "Drugs and Treatments - Nasacort AQ Nasl - Patient Handout". WebMD. Retrieved 2008-03-24. 

External links[edit]