Trade names Kenalog Nasacort
Routes Oral, topical,
IM, intra-articular, intrasynovial
Protein binding 68%
Half-life 88 minutes
Excretion Fecal and
A01 AC01 C05 , AA12 D07 , AB09 H02 , AB08 R01 , AD11 R03 , BA06 S01 BA05
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(8 S,9 R,10 S,11 S,13 S,14 S,16 R,17 S)-9-fluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3 H-cyclopenta[ a]phenanthren-3-one; (1 R,2 S,10 S,11 S,13 R,14 S,15 S,17 S)-1-fluoro-13,14,17-trihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[126.96.36.199 2,7.0 11,15]heptadeca-3,6-dien-5-one
C 21 H 27 F O 6
Molecular mass 394.434 g/mol
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Triamcinolone is a long-acting synthetic corticosteroid given orally, by injection, by inhalation, or as a topical ointment or cream.
Triamcinolone is used to treat a number of different medical conditions, such as
eczema, psoriasis, arthritis, allergies, ulcerative colitis, lupus, sympathetic ophthalmia, temporal arteritis, uveitis, ocular inflammation, Urushiol-induced contact dermatitis, aphthous ulcers (usually as triamcinolone acetonide), visualization during vitrectomy and the prevention of asthma attacks. It will not treat an asthma attack once it has already begun. [1 ] [2 ] It has also been used off-label for [3 ] macular degeneration. [4 ]
Prior to 2007 it was sold under the name Azmacort as a
corticosteroid inhaler for asthma long-term care.
TEVA and Perrigo launched the first generic inhalable triamcinolone. [5 ]
Triamcinolone is used to alleviate infection-induced eczema in fungal skin infections in the
combination drug of econazole/triamcinolone.
derivative triamcinolone acetonide is one of the ingredients of Ledermix, an endodontic (tooth's root canal) lotion used between sessions, and Sanofi sold it under the brand name Nasacort. Triamcinolone acetonide is also used as intra lesional steroid injection to treat keloids and hypertrophic scars
Different triamcinolone derivatives are available, including
acetonide, benetonide, furetonide, hexacetonide and diacetate.
Triamcinolone acetonide is a more potent type of triamcinolone, being about eight times as effective as prednisone.
Side effects [ edit ]
Side effects of triamcinolone include
sore throat, nosebleeds, increased coughing, headache, and runny nose. White patches in the throat or nose indicate a serious side effect. Symptoms of an allergic reaction include rash, itch, swelling, severe dizziness, trouble breathing. An additional side effect for women is a prolonged menstrual cycle. [6 ]
Trade names [ edit ]
Trade names for triamcinolone include Aristocort (Sandoz, now
Novartis), Kenacort ( Bristol-Myers Squibb), Kenalog ( Bristol-Myers Squibb), Tricort (Cadila), Triaderm ( Schering-Plough), Azmacort (KOS), Trilone, Volon A, Tristoject, Tricortone and Ratio-Triacomb.
See also [ edit ]
References [ edit ]
^ Triamcinolone - Drugs.com
^ Triamcinolone Inhalation - Drugs.com
^ Alcon Receives FDA Approval of Triesence Injectable Triamcinolone Suspension for Use in Eye Surgery - Drugs.com
^ Age-Related Macular Degeneration (AMD) Treatment
^ Perrigo Announces Launch Of Generic Version Of Nasacort AQ - CBS Detroit
^ "Drugs and Treatments - Nasacort AQ Nasl - Patient Handout". WebMD . Retrieved . 2008-03-24
External links [ edit ]