|Jmol-3D images||Image 1|
|Molar mass||434.50 g mol−1|
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Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Triamcinolone acetonide is a synthetic corticosteroid used to treat various skin conditions, to relieve the discomfort of mouth sores, and in nasal spray form, to treat allergic rhinitis. It is a more potent derivative of triamcinolone, and is about 8 times as potent as prednisone.
It is also known under the brand names Kenalog and Volon A as an injection to treat allergies, arthritis, eye diseases, intestinal problems and skin diseases. In 2014, the FDA made triamcinolone acetonide an over-the-counter drug in the USA in nasal spray form under the brand name Nasacort.
Triamcinolone acetonide should not be used by those with tuberculosis or untreated fungal, bacterial, systemic viral or herpes simplex infections without consulting a doctor first. Few serious adverse effects were noted in clinical trials with intranasal formulations; these include pharyngitis, rhinitis, headache and epistaxis as the more common ones. Overdosage is unlikely. Uncommonly, systemic effects associated with corticosteroids can occur when triamcinolone acetonide is administered in large doses and/or over a long period of time. As an intravitreal injection, triamcinolone has been used to treat various eye diseases and has been found useful in reducing macular edema. Drug trials have found it to be as efficient as anti-VEGF drugs in eyes with artificial lenses over a 2-year period. Complications of its use in the eye include cataract and glaucoma. Triamcinolone acetonide as an intraarticular injectable has been used to treat a variety of musculoskeletal conditions.
When applied as a topical ointment @ USP,0.1% it is used for blistering from poison ivy, oak, and sumac. Applied to skin avoiding eyes, mouth, and genital area. Provides immediate relief and is used before going to oral prednisone.
Uncommonly Intramuscular injection of triamcinolone acetonide may be indicated for the control of severe or incapacitating allergic states for which conventional treatments have failed, such as asthma, atopic dermatitis, contact dermatitis, perennial or seasonal allergic rhinitis, serum sickness, and transfusion and drug hypersensitivity reactions.
Common side effects of triamcinolone acetonide include sore throat, nosebleeds, increased coughing, headache, and runny nose. If these side effects occur, users are advised to consult their medical doctors where possible. Overuse or prolonged use of triamcinolone acetonide significantly increases the risk of side effects, as does dehydration.
Rarer, more serious side effects include opportunistic infections (due to suppression of immune responses) and anaphylaxis. If these life threatening side effects occur, users must seek emergency medical services. Users should not attempt complex tasks (such as driving) while experiencing these side effects, and persons suffering from these effects should request transport to a hospital from acquaintances or emergency services using emergency telephone numbers.
As with all immunosuppressant drugs, triamcinolone acetonide should not be taken when sick or when illness has recently passed. Contact with sick persons should be avoided during the entire course of treatment. While using triamcinolone acetonide, even minor illnesses (e.g. common cold) can be very serious, and may sometimes become life threatening. Users who get sick during their regimen should contact their doctor to discuss whether to discontinue the prescription.
Triamcinolone acetonide should not be taken if the patient is also taking any other steroid or immunosuppresant, or if they have recently undergone any medical procedures involving the administration of steroids (e.g. nerve block).
Many drugs have been demonstrated to increase triamcinolone acetonide concentration in the blood to well above the intended level. Patients should inform doctors about any other drugs they are taking.
Triamcinolone acetonide is also used in veterinary medicine as an ingredient in topical ointments, also in topical sprays for control of pruritus in dogs. A series of injections with triamcinolone acetonide or another corticosteroid may reduce keloid size and irritation. It is also used as a pre-inductor and/or inductor of birth in cows.