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Systematic (IUPAC) name
3,4-dihydro-2H-benzo[e] [1,2,4]thiadiazine-
Clinical data
AHFS/ Micromedex Detailed Consumer Information
  • B (D if used to treat pregnancy-induced hypertension)
  • (Prescription only)
Oral (capsules, tablets, oral solution)
Pharmacokinetic data
Bioavailability Variably absorbed from GI tract
Excretion Primarily excreted unchanged in urine
133-67-5 YesY
PubChem CID 5560
DrugBank DB01021 N
ChemSpider 5359 N
KEGG D00658 N
Chemical data
Formula C8H8Cl3N3O4S2
380.6558 g/mol
 N (what is this?)  (verify)

Trichlormethiazide (INN, currently being sold under the brand names of Achletin, Diu-Hydrin and Triflumen) is a diuretic with properties similar to those of hydrochlorothiazide.[1] It is usually administered for the treatment of oedema (including that which is associated with heart failure, hepatic cirrhosis and corticosteroid therapy) and hypertension.[1] In veterinary medicine, trichlormethiazide can be combined with dexamethasone to be used on horses with mild swelling of distal limbs and general bruising.[2]

As a diuretic (in particular a thiazide), trichlormethiazide encourages water loss from the body.[1] Trichlormethiazide works by inhibiting Na+/Cl ion reabsorption from the distal tubules of the kidneys.[1] In addition, trichlormethiazide increases the excretion of potassium.[1]


Trichlormethiazide appears to block the active reabsorption of chloride and possibly sodium in the ascending loop of Henle. This results in excretion of sodium, chloride and water, and thus acts as a diuretic.[1] Although trichlormethiazide is used to treat


Trichlormethiazide is 1,1-dioxide 3,4-dihydro-3-(dichlormethyl)-6-chloro-2H-1,2,4-benzothiadiazin-7-sulfonamide.

Trichlormethiazide synthesis:[3][4][5][6][7][8]

Synonyms of this drug are esmarin, esmalorid, anatran, carvacron, intromene, sanamirone, methahydrin, naqua, triazide, and others.

See also[edit]


  1. ^ a b c d e f "DrugBank: DB01021 (Trichlormethiazide)". DrugBank. Retrieved 2008-01-23. 
  2. ^ "Trichlormethiazide and Dexamethasone for veterinary use". Wedgewood Pharmacy. Retrieved 2008-01-24. 
  3. ^ Scherico Ltd., Br. GB 949373  (1960).
  4. ^ G. de Stevens, L.H. Werner, Ger. DE 1147233  (1960).
  5. ^ De Stevens, G; Werner, L. H.; Barrett, W. E.; Chart, J. J.; Renzi, A. H. (1960). "The chemistry and pharmacology of hydrotrichlorothiazide". Experientia 16: 113–4. PMID 13815073.  edit
  6. ^ M.H. Sherlock, N. Sperber, J. Topliss, Experientia, 16, 184 (1960).
  7. ^ Scherico Ltd., GB 954023  (1960).
  8. ^ W.J. Close, U.S. Patent 3,264,292 (1960).
  9. ^ "Epithiazide". Retrieved 2015-05-05.