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Systematic (IUPAC) name
Clinical data
AHFS/ Micromedex Detailed Consumer Information
Pregnancy cat.
  • B (D if used to treat pregnancy-induced hypertension)
Legal status
  • Prescription only
Routes Oral (capsules, tablets, oral solution)
Pharmacokinetic data
Bioavailability Variably absorbed from GI tract
Excretion Primarily excreted unchanged in urine
CAS number 133-67-5 YesY
ATC code C03AA03
PubChem CID 5560
DrugBank DB01021
ChemSpider 5359 N
KEGG D00658 N
Chemical data
Formula C8H8Cl3N3O4S2 
Mol. mass 380.6558 g/mol
 N (what is this?)  (verify)

Trichlormethiazide (INN, currently being sold under the brand names of Achletin, Diu-Hydrin and Triflumen) is a diuretic with properties similar to those of hydrochlorothiazide.[1] It is usually administered for the treatment of oedema (including that which is associated with heart failure, hepatic cirrhosis and corticosteroid therapy) and hypertension.[1] In veterinary medicine, trichlormethiazide can be combined with dexamethasone to be used on horses with mild swelling of distal limbs and general bruising.[2]

As a diuretic (in particular a thiazide), trichlormethiazide encourages water loss from the body.[1] Trichlormethiazide works by inhibiting Na+/Cl- ion reabsorption from the distal tubules of the kidneys.[1] In addition, trichlormethiazide increases the excretion of potassium.[1]


Trichlormethiazide appears to block the active reabsorption of chloride and possibly sodium in the ascending loop of Henle. This results in excretion of sodium, chloride and water, and thus acts as a diuretic.[1] Although trichlormethiazide is used to treat


Trichlormethiazide is 1,1-dioxide 3,4-dihydro-3-(dichlormethyl)-6-chloro-2H-1,2,4-benzothiadiazin-7-sulfonamide.

  • Scherico Ltd., Br. GB 949373  (1960).
  • G. de Stevens, L.H. Werner, Ger. DE 1147233  (1960).
  • G. de Stevens, L.H. Werner, W.E. Barrett, J.J. Chest, A.H. Renzi, Experientia, 16, 113 (1960).
  • M.H. Sherlock, N. Sperber, J. Topliss, Experientia, 16, 184 (1960).
  • Scherico Ltd., Br. GB 954023  (1960).
  • W.J. Close, U.S. Patent 3,264,292 (1960).

Synonyms of this drug are esmarin, esmalorid, anatran, carvacron, intromene, sanamirone, methahydrin, naqua, triazide, and others.


  1. ^ a b c d e f "DrugBank: DB01021 (Trichlormethiazide)". DrugBank. Retrieved 2008-01-23. 
  2. ^ "Trichlormethiazide and Dexamethasone for veterinary use". Wedgewood Pharmacy. Retrieved 2008-01-24.