Trichomoniasis
| Trichomoniasis | |
|---|---|
| Classification and external resources | |
 Micrograph showing a positive result for trichomoniasis. A trichomonas organism is seen on the top-right of the image. |
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| ICD-10 | A59 |
| ICD-9 | 131,007.3 |
| DiseasesDB | 13334 |
| eMedicine | med/2308 emerg/613 |
| MeSH | D014246 |
Trichomoniasis, sometimes referred to as "trich", is a common cause of vaginitis. It is a sexually transmitted disease, and is caused by the single-celled protozoan parasite Trichomonas vaginalis producing mechanical stress on host cells and then ingesting cell fragments after cell death.[1] Trichomoniasis is primarily an infection of the urogenital tract; the most common site of infection is the urethra and the vagina in women.
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[edit] Symptoms
Typically, only women experience symptoms associated with Trichomonas infection. Symptoms include inflammation of the cervix (cervicitis), urethra (urethritis), and vagina (vaginitis) which produce an itching or burning sensation. Discomfort may increase during intercourse and urination. There may also be a yellow-green, itchy, frothy foul-smelling ("fishy" smell) vaginal discharge. In rare cases, lower abdominal pain can occur. Symptoms usually appear in women within 5 to 28 days of exposure.[2] In many cases, men may hold the parasite for some years without any signs (dormant). Some sexual health specialists have stated that the condition can probably be carried in the vagina for years, despite standard tests being negative.[3] While symptoms are most common in women, some men may temporarily exhibit symptoms such as an irritation inside the penis, mild discharge, or slight burning after urination or ejaculation.[2]
[edit] Diagnosis
Trichomoniasis is diagnosed by visually observing the trichomonads via a microscope. In women, the examiner collects the specimen during a pelvic examination by inserting a speculum into the vagina and then using a cotton-tipped applicator to collect the sample. The sample is then placed onto a microscopic slide and sent to a laboratory to be analyzed. Examination may also reveal small red ulcerations on the vaginal wall or cervix.
Trichomoniasis has been difficult to diagnose due to the poor sensitivity of the tests; in 2011 a study reported a more reliable test.[4]
[edit] Causes and risk factors
The human genital tract is the only reservoir for this species. Trichomonas is transmitted through sexual or genital contact.[5]
[edit] Genetic sequence
A draft sequence of the Trichomonas genome was published on January 12, 2007 in the journal Science confirming that the genome has at least 26,000 genes, a similar number to the human genome.[6]
[edit] Treatment
Treatment for both pregnant and non-pregnant patients usually utilizes metronidazole (Flagyl) but with caution especially in early stages of pregnancy[7] 2000 mg by mouth once. Sexual partners, even if asymptomatic, should be concurrently treated.[8]
Although both men and women are susceptible to suffer the infection, it is suspected that more than one half of men who are infected will naturally expel the parasite within 14 days,[9] while in women it will persist unless treated.
[edit] Complications
Research has shown a link between trichomoniasis and two serious sequelæ. Data suggest that:
- Trichomoniasis is associated with increased risk of transmission of HIV.
- Trichomoniasis may cause a woman to deliver a low-birth-weight or premature infant.
- Trichomoniasis is also associated with increased chances of cervical cancer
- Evidence implies that infection in males potentially raises the risks of prostate cancer development and spread due to inflammation.[10]
Additional research is needed to fully explore these relationships.
[edit] Prevalence and prevention
The American Social Health Association estimates trichomoniasis affects 7.4 million previously unaffected Americans each year and is the most frequently presenting new infection of the common sexually transmitted diseases.[11]
Use of male condoms may help prevent the spread of trichomoniasis,[12] although careful studies have never been done that focus on how to prevent this infection. Infection with Trichomoniasis through water is unlikely because Trichomonas vaginalis dies in water after 45–60 minutes, in thermal water after 30 minutes to 3 hours and in diluted urine after 5–6 hours.[8] Treatment is usually Metronidazole.[13]
[edit] References
- ^ Midlej V., Benchimol M. (2010). "Trichomonas vaginalis kills and eats- evidence for phagocytic activity as a cytopathic effect". Parasitology 137 (1): 65–76. doi:10.1017/S0031182009991041. PMID 19723359.
- ^ a b Trichomoniasis symptoms. cdc.gov
- ^ [1]. Can trichomoniasis be dormant? MedHelp
- ^ Andrea SB, Chapin KC (2011). "Comparison of Aptima Trichomonas vaginalis Transcription-Mediated Amplification Assay and BD Affirm VPIII for Detection of T. vaginalis in Symptomatic Women: Performance Parameters and Epidemiological Implications.". J Clin Microbiol 49 (3): 866–9. doi:10.1128/JCM.02367-10. PMID 21248097. Lay summary.
- ^ "Trichomoniasis - CDC Fact Sheet". http://www.cdc.gov/std/trichomonas/STDFact-Trichomoniasis.htm. Retrieved 12 January 2011.
- ^ Scientists crack the genome of the parasite causing trichomoniasis. Physorg.com. Jan. 12, 2007.
- ^ Cudmore SL, Delgaty KL, Hayward-McClelland SF, Petrin DP, Garber GE (October 2004). "Treatment of infections caused by metronidazole-resistant Trichomonas vaginalis". Clin. Microbiol. Rev. 17 (4): 783–93, table of contents. doi:10.1128/CMR.17.4.783-793.2004. PMC 523556. PMID 15489348. http://cmr.asm.org/cgi/pmidlookup?view=long&pmid=15489348.
- ^ a b Rob, Lukáš; Martan, Alois; Citterbart, Karel et al. (2008) (in Czech). Gynekologie (2nd ed.). Prague: Galen. p. 136. ISBN 978-80-7262-501-7.
- ^ Heather Feldman. Scientists fighting STD with research, education. http://www.uthscsa.edu/mission/spring00/std.htm.
- ^ LittleAbout, Boffins find link between common sexual infection, prostate cancer risk, Retrieved Sept 17 2009.
- ^ Associated Press, Abstinence students still having sex, MSNBC, April 16, 2007. Retrieved March 12, 2008.
- ^ Vaginitis/Trichomoniasis :Reduce your risk, American Social Health Association. Retrieved March 12, 2008.
- ^ Vaginitis/Trichomoniasis :Treatment for trichomoniasis, American Social Health Association. Retrieved March 12, 2008.
[edit] External links
- Trichomoniasis at Centers for Disease Control and Prevention
- Vaginitis/Vaginal infection fact sheet from the National Institute of Allergies and Infections. The first version of this article was taken from this public domain resource.
- eMedicine Health Trichomoniasis
- Trichomonas columbae video
- Can trichomoniasis be dormant?
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