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Trifolin structure
CAS number 23627-87-4
PubChem 5282149
ChemSpider 10306173
ChEBI CHEBI:31742 YesY
Jmol-3D images Image 1
Molecular formula C21H20O11
Molar mass 448.37 g/mol
Density 1.791 g/mL
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

Trifolin is a chemical compound. It is the kaempferol 3-galactoside. It can be found in Camptotheca acuminata,[1] in Euphorbia condylocarpa[2] or in Consolida oliveriana.[3]

Kaempferol 3-O-galactosyltransferase is an enzyme that catalyzes the chemical reaction:
UDP-galactose + kaempferol → UDP + kaempferol 3-O-beta-D-galactoside (trifolin).[4] It can also be found in seedlings of Vigna mungo.[5]


  1. ^ Li, S.; Zhang, Z.; Cain, A.; Wang, B.; Long, M.; Taylor, J. (2005). "Antifungal Activity of Camptothecin, Trifolin, and Hyperoside Isolated fromCamptotheca acuminata". Journal of Agricultural and Food Chemistry 53 (1): 32–37. doi:10.1021/jf0484780. PMID 15631505.  edit
  2. ^ Roshchin, Y. V. (1977). "Trifolin from Euphorbia condylocarpa". Chemistry of Natural Compounds 13 (4): 481–482. doi:10.1007/BF00565849.  edit
  3. ^ Díaz, J. S.; Carmona, A.; Torres, F.; Quintana, J.; Estévez, F.; Herz, W. (2008). "Cytotoxic Activities of Flavonoid Glycoside Acetates from Consolida oliveriana". Planta Medica 74 (2): 171–174. doi:10.1055/s-2008-1034278. PMID 18214815.  edit
  4. ^ Miller, K. D.; Guyon, V.; Evans, J. N.; Shuttleworth, W. A.; Taylor, L. P. (1999). "Purification, Cloning, and Heterologous Expression of a Catalytically Efficient Flavonol 3-O-Galactosyltransferase Expressed in the Male Gametophyte of Petunia hybrida". Journal of Biological Chemistry 274 (48): 34011–34019. doi:10.1074/jbc.274.48.34011. PMID 10567367.  edit
  5. ^ Partial Purification and Some Properties of Flavonol 3-O-Glycosyltransferases from Seedlings of Vigna mungo, with Special Reference to the Formation of Kaempferol 3-O-Galactoside and 3-O-Glucoside. Nariyuki Ishikura and Masami Mato, Plant Cell Physiol, 1993, 34 (2), pages 329-335, (abstract)