Trioxifene

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Trioxifene
Trioxifene.png
Systematic (IUPAC) name
[2-(4-methoxyphenyl)-3,4-dihydronaphthalen-1-yl]-[4-(2-pyrrolidin-1-ylethoxy)phenyl]methanone
Clinical data
Legal status
  • Uncontrolled
Routes Oral
Identifiers
CAS number 63619-84-1
ATC code None
PubChem CID 50139
ChemSpider 45471
UNII R0130F043H YesY
Chemical data
Formula C30H31NO3 
Mol. mass 453.57 g/mol

Trioxifene (LY-133,314) is a selective estrogen receptor modulator (SERM) with competitive binding activity against estradiol for estrogen receptor {alpha} (ER{alpha}) and antagonistic activity against ER{alpha}-mediated gene expression. It has demonstrated anticancer effects in animal studies,[1] indicating that it may be useful for the treatment of breast cancer.

See also[edit]

References[edit]

  1. ^ Neubauer BL, McNulty AM, Chedid M, Chen K, Goode RL, Johnson MA, Jones CD, Krishnan V, Lynch R, Osborne HE, Graff JR (September 2003). "The selective estrogen receptor modulator trioxifene (LY133314) inhibits metastasis and extends survival in the PAIII rat prostatic carcinoma model". Cancer Research 63 (18): 6056–62. PMID 14522935.