Tripeptidyl peptidase II

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Tripeptidyl peptidase II
Symbols TPP2 ; TPP-2
External IDs OMIM190470 MGI102724 HomoloGene2471 ChEMBL: 6156 GeneCards: TPP2 Gene
EC number
RNA expression pattern
PBB GE TPP2 203375 s at tn.png
PBB GE TPP2 203374 s at tn.png
More reference expression data
Species Human Mouse
Entrez 7174 22019
Ensembl ENSG00000134900 ENSMUSG00000041763
UniProt P29144 Q64514
RefSeq (mRNA) NM_003291 NM_009418
RefSeq (protein) NP_003282 NP_033444
Location (UCSC) Chr 13:
103.25 – 103.33 Mb
Chr 1:
43.93 – 44 Mb
PubMed search [1] [2]

Tripeptidyl-peptidase 2 is an enzyme that in humans is encoded by the TPP2 gene.[1][2] Among other things it is heavily implicated in MHC (HLA) class-I processing, as it has both endopeptidase and exopeptidase activity.[3]


  1. ^ Tomkinson B, Jonsson AK (Feb 1991). "Characterization of cDNA for human tripeptidyl peptidase II: the N-terminal part of the enzyme is similar to subtilisin". Biochemistry 30 (1): 168–74. doi:10.1021/bi00215a025. PMID 1670990. 
  2. ^ "Entrez Gene: TPP2 tripeptidyl peptidase II". 
  3. ^ Reits E; Neijssen J; Herberts C et al. (April 2004). "A major role for TPPII in trimming proteasomal degradation products for MHC class I antigen presentation". Immunity 20 (4): 495–506. doi:10.1016/S1074-7613(04)00074-3. PMID 15084277. 

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: S08.090

Further reading[edit]