Abacavir/lamivudine/zidovudine

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Abacavir/lamivudine/zidovudine
Combination of
Abacavir	Nucleotide analogue reverse transcriptase inhibitor
Lamivudine	Nucleoside analogue reverse transcriptase inhibitor
Zidovudine	Nucleoside analogue reverse transcriptase inhibitor
Clinical data
MedlinePlus	a687007
Pregnancy cat.	C(US)
Legal status	POM (UK) ℞-only (US)
Routes	Oral
Identifiers
ATC code	J05AR04
ChemSpider	21106400^Y
NIAID ChemDB	AIDSNO:058986
Y(what is this?) (verify)

Abacavir/lamivudine/zidovudine (INNs, trade name Trizivir) is a pharmaceutical treatment for HIV infection. It is a fixed dose combination of three reverse transcriptase inhibitors patented by GlaxoSmithKline and now marketed by its joint venture with Pfizer, ViiV Healthcare:

abacavir ("ABC")
lamivudine ("3TC")
zidovudine ("AZT")

It is indicated in the treatment of AIDS/HIV.

The combination of drugs is helpful in that it helps to reduce HIV's resistance (through mutation) to the drugs individually. Of the three, AZT and ABC have passed out of United States patent protection.

Antiviral drugs: antiretroviral drugs used against HIV (primarily J05)

Entry/fusion inhibitors
(Discovery & development)

gp41 (Enfuvirtide) • CCR5 (Maraviroc, Vicriviroc^†, Cenicriviroc^†, PRO 140^†) • CD4 (Ibalizumab^†)

Reverse-transcriptase
inhibitors (RTIs)

Nucleoside & Nucleotide (NRTI)	Nucleoside analogues/NARTIs: Abacavir (ABC)°^# • Emtricitabine (FTC)°^# • Lamivudine (3TC)°^# • Didanosine (ddI)^# • Zidovudine (AZT)^# • Apricitabine^† • Stampidine^† • Elvucitabine^† • Racivir^† • Amdoxovir^†• Stavudine (d4T)^# • Zalcitabine (ddC)^◊ • Festinavir^† Nucleotide analogues/NtRTIs: Tenofovir°^# • GS 7340

Non-Nucleoside (NNRTI) (Discovery & development)	(1^st generation) Efavirenz°^# • Nevirapine^# • Loviride^◊ • Delavirdine^◊ • (2^nd generation) diarylpyrimidines (Etravirine, Rilpivirine) • Lersivirine^†

Integrase inhibitors

Raltegravir • Elvitegravir^† • Dolutegravir^† • Globoidnan A (experimental) • MK-2048^† • BI 224436^†

Maturation inhibitors

Bevirimat^† • Vivecon^†

Protease Inhibitors (PI)
(Discovery and development)

1^st generation	Fosamprenavir° • Lopinavir°^# • Nelfinavir^# • Ritonavir^# • Saquinavir^# • Amprenavir^◊ • Indinavir^◊^#

2^nd generation	Atazanavir° • Darunavir • Tipranavir

Combined formulations

Lamivudine/zidovudine • Emtricitabine/tenofovir/efavirenz • Abacavir/lamivudine/zidovudine • Tenofovir/emtricitabine • Lopinavir/ritonavir • Abacavir/lamivudine • Emtricitabine/rilpivirine/tenofovir

Experimental agents

Uncoating inhibitors	TRIM5alpha (gene)

Transcription inhibitors	Tat antagonists

Translation inhibitors	Trichosanthin

Other	Abzyme • Calanolide A • Ceragenin • Cyanovirin-N • Diarylpyrimidines • Epigallocatechin gallate (EGCG) • Foscarnet • Griffithsin • Hydroxycarbamide • Miltefosine • Portmanteau inhibitors • Seliciclib^† • Synergistic enhancers • Tre recombinase • Zinc finger protein transcription factor • KP-1461^† • Cobicistat^†

Failed agents	Dexelvucitabine • Capravirine • Emivirine • Lodenosine • Atevirdine • Brecanavir • Aplaviroc