Trolamine salicylate

Trolamine salicylate
IUPAC name Tris(2-hydroxyethyl)ammonium 2-hydroxybenzoate
Identifiers
CAS number	2174-16-5 Y
PubChem	25213
ChemSpider	23549 Y
Jmol-3D images	Image 1
SMILES O=C(O)c1ccccc1O.OCCN(CCO)CCO
InChI InChI=1S/C7H6O3.C6H15NO3/c8-6-4-2-1-3-5(6)7(9)10;8-4-1-7(2-5-9)3-6-10/h1-4,8H,(H,9,10);8-10H,1-6H2 Y Key: UEVAMYPIMMOEFW-UHFFFAOYSA-N Y InChI=1/C7H6O3.C6H15NO3/c8-6-4-2-1-3-5(6)7(9)10;8-4-1-7(2-5-9)3-6-10/h1-4,8H,(H,9,10);8-10H,1-6H2 Key: UEVAMYPIMMOEFW-UHFFFAOYAM
Properties
Molecular formula	C13H21NO6
Molar mass	287.31 g/mol
Y (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Trolamine salicylate is an organic compound which is the salt formed between triethanolamine and salicylic acid.

It is used as an ingredient in sunscreens, analgesic creams, and cosmetics. The salicylic acid portion contributes to both the sun protection effect (by absorbing UVB rays) and to the analgesic effect. The triethanolamine neutralizes the acidity of the salicylic acid. One benefit of this topical analgesic is that it has no odor, in contrast to other topical analgesics such as menthol.

The US Food and Drug Administration has not reviewed any of the over-the-counter products listed in the DailyMed database that contain trolamine salicylate. Also, the producers of trolamine salicylate products have not provided evidence to the FDA in support of claims that this chemical is directly absorbed through the skin into underlying tissue.. However, one study ("Effect of a Topical 10% Trolamine Salicylate Cream on Delayed Onset Muscular Soreness", Medicine and Science in Sports and Exercise, vol. 20(2), Supplement, #141 (1988)) reported that trolamine salicylate does penetrate into, and persist within, underlying muscle tissue. The test subjects used either the trolamine salicylate product or a placebo while engaging in an exercise regimen designed to induce muscle soreness. The experimenters observed that those using the trolamine salicylate product reported slower onset of soreness, reduced levels of soreness, and reduced duration of soreness as compared to those using the placebo.

All the trolamine salicylate-containing products listed in the two cited references are 10% solutions. Such products carry various brand names, and are marketed as topical analgesics for relief of temporary muscle soreness.