Tromantadine
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| Systematic (IUPAC) name | |
|---|---|
| N-1-adamantyl-N-[2-(dimethylamino)ethoxy]acetamide | |
| Identifiers | |
| CAS number | 53783-83-8 |
| ATC code | D06BB02 |
| PubChem | 64377 |
| Chemical data | |
| Formula | C16H28N2O2 |
| Mol. mass | 280.406 g/mol |
| SMILES | eMolecules & PubChem |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | Topical |
Tromantadine is an antiviral medicine used to treat herpes simplex virus. It is available in a topical gel under trade name Viru-Merz. Its performance is similar to aciclovir.
Like rimantadine and amantadine, tromantadine is a derivative of adamantane.
[edit] Mechanism
Tromantadine inhibits the early and late events in the virus replication cycle.[1] It changes the glycoproteins of the host cells, therefore impeding the absorption of the virus. It inhibits penetration of the virus. It also prevents uncoating of the virions.
[edit] References
- ^ Rosenthal KS, Sokol MS, Ingram RL, Subramanian R, Fort RC (December 1982). "Tromantadine: inhibitor of early and late events in herpes simplex virus replication". Antimicrob. Agents Chemother. 22 (6): 1031–6. PMID 6297383. PMC 185716. http://aac.asm.org/cgi/pmidlookup?view=long&pmid=6297383.
[edit] External links
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