Tromantadine

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Tromantadine
Systematic (IUPAC) name
N-1-adamantyl-N-[2-(dimethylamino)ethoxy]acetamide
Identifiers
CAS number 53783-83-8
ATC code D06BB02
PubChem 64377
Chemical data
Formula C16H28N2O2 
Mol. mass 280.406 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

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Legal status
Routes Topical

Tromantadine is an antiviral medicine used to treat herpes simplex virus. It is available in a topical gel under trade name Viru-Merz. Its performance is similar to aciclovir.

Like rimantadine and amantadine, tromantadine is a derivative of adamantane.

[edit] Mechanism

Tromantadine inhibits the early and late events in the virus replication cycle.[1] It changes the glycoproteins of the host cells, therefore impeding the absorption of the virus. It inhibits penetration of the virus. It also prevents uncoating of the virions.

[edit] References

  1. ^ Rosenthal KS, Sokol MS, Ingram RL, Subramanian R, Fort RC (December 1982). "Tromantadine: inhibitor of early and late events in herpes simplex virus replication". Antimicrob. Agents Chemother. 22 (6): 1031–6. PMID 6297383. PMC 185716. http://aac.asm.org/cgi/pmidlookup?view=long&pmid=6297383. 

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