Tromantadine

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Tromantadine
Skeletal formula
Ball-and-stick model
Systematic (IUPAC) name
N-1-adamantyl-N-[2-(dimethylamino)ethoxy]acetamide
Clinical data
AHFS/Drugs.com International Drug Names
Legal status
?
Routes Topical
Identifiers
CAS number 53783-83-8 N
ATC code D06BB02 J05AC03
PubChem CID 64377
ChemSpider 57947 YesY
UNII H191JFG8WA YesY
KEGG D07199 YesY
NIAID ChemDB 007760
Chemical data
Formula C16H28N2O2 
Mol. mass 280.406 g/mol
 N (what is this?)  (verify)

Tromantadine is an antiviral medicine used to treat herpes simplex virus. It is available in a topical gel under trade name Viru-Merz. Its performance is similar to aciclovir.

Like rimantadine and amantadine, tromantadine is a derivative of adamantane.

Mechanism[edit]

Tromantadine inhibits the early and late events in the virus replication cycle.[1] It changes the glycoproteins of the host cells, therefore impeding the absorption of the virus. It inhibits penetration of the virus. It also prevents uncoating of the virions.

References[edit]

  1. ^ Rosenthal KS, Sokol MS, Ingram RL, Subramanian R, Fort RC (December 1982). "Tromantadine: inhibitor of early and late events in herpes simplex virus replication". Antimicrob. Agents Chemother. 22 (6): 1031–6. doi:10.1128/aac.22.6.1031. PMC 185716. PMID 6297383. 

External links[edit]