Troponin C type 1

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Troponin C type 1 (slow)
Protein TNNC1 PDB 1aj4.png
PDB rendering based on 1aj4.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols TNNC1 ; CMD1Z; CMH13; TN-C; TNC; TNNC
External IDs OMIM191040 MGI98779 HomoloGene55728 ChEMBL: 2066 GeneCards: TNNC1 Gene
RNA expression pattern
PBB GE TNNC1 209904 at tn.png
More reference expression data
Species Human Mouse
Entrez 7134 21924
Ensembl ENSG00000114854 ENSMUSG00000091898
UniProt P63316 P19123
RefSeq (mRNA) NM_003280 NM_009393
RefSeq (protein) NP_003271 NP_033419
Location (UCSC) Chr 3:
52.49 – 52.49 Mb
Chr 14:
31.21 – 31.21 Mb
PubMed search [1] [2]

Troponin C, slow skeletal and cardiac muscles is a protein that in humans is encoded by the TNNC1 gene.[1]


Troponin C type 1 has been shown to interact with TNNI3.[2][3][4][5][6]


  1. ^ "Entrez Gene: TNNC1 troponin C type 1 (slow)". 
  2. ^ Ward, Douglas G; Brewer Susan M; Gallon Clare E; Gao Yuan; Levine Barry A; Trayer Ian P (May 2004). "NMR and mutagenesis studies on the phosphorylation region of human cardiac troponin I". Biochemistry (United States) 43 (19): 5772–81. doi:10.1021/bi036310m. ISSN 0006-2960. PMID 15134451. 
  3. ^ Ward, Douglas G; Brewer Susan M; Calvert Melanie J; Gallon Clare E; Gao Yuan; Trayer Ian P (Apr 2004). "Characterization of the interaction between the N-terminal extension of human cardiac troponin I and troponin C". Biochemistry (United States) 43 (13): 4020–7. doi:10.1021/bi036128l. ISSN 0006-2960. PMID 15049709. 
  4. ^ Ward, Douglas G; Brewer Susan M; Cornes Michael P; Trayer Ian P (Sep 2003). "A cross-linking study of the N-terminal extension of human cardiac troponin I". Biochemistry (United States) 42 (34): 10324–32. doi:10.1021/bi034495r. ISSN 0006-2960. PMID 12939162. 
  5. ^ Wang, Xu; Li Monica X; Sykes Brian D (Aug 2002). "Structure of the regulatory N-domain of human cardiac troponin C in complex with human cardiac troponin I147-163 and bepridil". J. Biol. Chem. (United States) 277 (34): 31124–33. doi:10.1074/jbc.M203896200. ISSN 0021-9258. PMID 12060657. 
  6. ^ Li, Monica X; Saude Erik J; Wang Xu; Pearlstone Joyce R; Smillie Lawrence B; Sykes Brian D (Jul 2002). "Kinetic studies of calcium and cardiac troponin I peptide binding to human cardiac troponin C using NMR spectroscopy". Eur. Biophys. J. (Germany) 31 (4): 245–56. doi:10.1007/s00249-002-0227-1. ISSN 0175-7571. PMID 12122471. 

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