From the north side of the Keihin-Tōhoku Line platform are located, in order, The Tokaido Line passenger train lines in both directions, The Tokaido Line Tokyo-bound freight train tracks, three tracks for trains to stop at overnight, and the Tokaido Line freight train tracks for the direction from Tokyo. None of these have platforms.
Between the Keihin-Tōhoku Line and Tsurumi Line there is a ticket gate, which is a remnant of when the Tsurumi Line was operated by the separate Tsurumi Rinkō Tetsudō Kabushiki Gaisha(鶴見臨港鉄道株式会社?).
There is a Midori no Madoguchi staffed ticket office as well as automatic ticket gates. The Keihin-Tōhoku Line platforms are connected to the concourse by escalators and elevators.
Tsurumi Station was opened on November 15, 1872 as a station on the Japanese Government Railways (the predecessor to the Japanese National Railways) Tōkaidō Main Line, initially for passenger operations only. Freight services started on April 1, 1898. The Keihin Line began operations to Tsurumi from December 20, 1914. On December 23, 1934, the Tsurumi Rinkō Railway (present-day Tsurumi Line) connected to Tsurumi Station. The station was the location of a major railway accident, the Tsurumi Accident on November 9, 1963. It was one of the five major post-war JNR accidents. Upon the privatization of JNR on April 1, 1987 the station has been operated by JR East.