Tumor necrosis factor receptor

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TNFR/NGFR cysteine-rich region
PDB 1tnr EBI.jpg
Structure of the soluble human 55 kd TNF receptor-human TNF beta complex.[1]
Identifiers
Symbol TNFR_c6
Pfam PF00020
InterPro IPR011614
PROSITE PDOC00561
SCOP 1tnr
SUPERFAMILY 1tnr

A tumor necrosis factor receptor (TNFR), or death receptor, is a trimeric[2] cytokine receptor that binds tumor necrosis factors (TNF). The receptor cooperates with an adaptor protein (such as TRADD, TRAF, RIP), which is important in determining the outcome of the response (e.g. apoptosis, inflammation).

Because "TNF" is often used to describe TNF alpha, "TNFR" is often used to describe the receptors that bind to TNF alpha - namely, CD120. However, there are several other members of this family that bind to the other TNFs.[3][4]

Members[edit]

Family members include:[3]

Type Protein Aliases Gene
1 (CD120) CD120a TNFRSF1A
CD120b TNFRSF1B
3 Lymphotoxin β receptor TNFRSF3 LTBR
4 CD134 TNFRSF4
5 CD40 TNFRSF5 CD40
6 FAS TNFRSF6 FAS
TNFRSF6B TNFRSF6B
7 CD27 TNFRSF7 CD27
8 CD30 TNFRSF8
9 CD137 TNFRSF9
10 TNFRSF10A DR4 TNFRSF10A
TNFRSF10B DR5 TNFRSF10B
TNFRSF10C TNFRSF10C
TNFRSF10D TNFRSF10D
11 RANK TNFRSF11A
Osteoprotegerin TNFRSF11B
12 TNFRSF12A Fn14 TNFRSF12A
13 TNFRSF13B TNFRSF13B
TNFRSF13C TNFRSF13C
14 TNFRSF14 TNFRSF14
16 Nerve growth factor receptor TNFRSF16 NGFR
17 TNFRSF17 TNFRSF17
18 TNFRSF18 TNFRSF18
19 TNFRSF19 TNFRSF19
21 TNFRSF21 DR6 TNFRSF21
25 TNFRSF25 DR3 TRAMP LARD WS-1[5] TNFRSF25
27 Ectodysplasin A2 receptor TNFRSF27 EDA2R

References[edit]

  1. ^ Banner DW, D'Arcy A, Janes W et al. (May 1993). "Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation". Cell 73 (3): 431–45. doi:10.1016/0092-8674(93)90132-A. PMID 8387891. 
  2. ^ Ashkenazi, A.; Dixit, VM (1998). "Death Receptors: Signaling and Modulation". Science 281 (5381): 1305–8. doi:10.1126/science.281.5381.1305. PMID 9721089. 
  3. ^ a b Locksley RM, Killeen N, Lenardo MJ (2001). "The TNF and TNF receptor superfamilies: integrating mammalian biology". Cell 104 (4): 487–501. doi:10.1016/S0092-8674(01)00237-9. PMID 11239407. 
  4. ^ Hehlgans T, Pfeffer K (2005). "The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games". Immunology 115 (1): 1–20. doi:10.1111/j.1365-2567.2005.02143.x. PMC 1782125. PMID 15819693. 
  5. ^ Marsters. "Identification of a ligand for the death-domain-containing receptor Apo3". current biology. Retrieved 4 December 2013. 

Further reading[edit]

External links[edit]