21st Century Medicine
21st Century Medicine (21CM) is a California cryobiological research company which has as its primary focus the development of perfusates and protocols for viable long-term cryopreservation of human organs, tissues and cells at cryogenic temperatures (temperatures below −100°C) through the use of vitrification. 21CM was founded in 1993.
Dr. Gregory M. Fahy, the world's foremost expert in organ cryopreservation by vitrification, serves on the company’s Board of Directors and prioritizes, develops and directs the company’s research activities. He also manages all extramural collaborative research projects with universities, industry and research institutions to create specific products and services.
The company holds a number of patents, most notably for cryoprotectant mixtures that greatly reduce ice formation while minimizing cryoprotectant toxicity, as well as for synthetic ice-blockers that inexpensively simulate the antifreeze protein found in arctic organisms. Their website lists peer-reviewed journal publications based on research conducted in their laboratories. In 2004 21CM received a $900,000 grant from the U.S. National Institutes of Health (NIH) to study a preservation solution developed by the University of Rochester in New York for extending simple cold storage time of human hearts removed for transplant.
At the July 2005 annual conference of the Society for Cryobiology, 21st Century Medicine announced the vitrification of a rabbit kidney to -135°C with their proprietary vitrification mixture. The kidney was successfully transplanted upon rewarming to a rabbit, with long-term life support functionality and viability.
- "21CM Publications". Archived from the original on 18 October 2006. Retrieved 2006-11-08.
- "NIH grant to be used for heart preservation research". Business Wire. October 31, 2004. Retrieved 2012-05-02.
- "Plenary Session: Fundamentals of Biopreservation". CRYO 2005 Scientific Program. Society for Cryobiology. July 24, 2005. Archived from the original on 2006-08-30. Retrieved 2006-11-08.
- Fahy GM, Wowk B, Pagotan R, Chang A, Phan J, Thomson B, Phan L (2009). "Physical and biological aspects of renal vitrification". ORGANOGENESIS 5 (3): 167–175. doi:10.4161/org.5.3.9974. PMC 2781097. PMID 20046680.