Tandem pore domain potassium channel
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(Redirected from Two P potassium channel)
The two-pore-domain potassium channel is a family of 15 members form what is known as "leak channels" which possess Goldman-Hodgkin-Katz (open) rectification.[1] These channels are regulated by several mechanisms including oxygen tension, pH, mechanical stretch, and G-proteins. Their name is derived from the fact that the α subunits consist of four transmembrane segments, each containing two pore loops. As such, they structurally correspond to two inward-rectifier α subunits and thus form dimers in the membrane.
Below is a list of the 15 known two-pore-domain human potassium channels:[1]
| Gene | Channel | Family | Aliases |
| KCNK1 | K2p1.1 | TWIK[2][3] | TWIK-1 |
| KCNK2 | K2p2.1 | TREK[2][3] | TREK-1 |
| KCNK3 | K2p3.1 | TASK[2][3] | TASK-1 |
| KCNK4 | K2p4.1 | TREK[2][3] | TRAAK[4] |
| KCNK5 | K2p5.1 | TASK[2][3] | TASK-2[5] |
| KCNK6 | K2p6.1 | TWIK[2][3] | TWIK-2 |
| KCNK7 | K2p7.1 | TWIK[2][3] | |
| KCNK9 | K2p9.1 | TASK[2][3] | TASK-3 |
| KCNK10 | K2p10.1 | TREK[2][3] | TREK-2 |
| KCNK12 | K2p12.1 | THIK | THIK-2 |
| KCNK13 | K2p13.1 | THIK | THIK-1 |
| KCNK15 | K2p15.1 | TASK[2][3] | TASK-5 |
| KCNK16 | K2p16.1 | TALK[2][3] | TALK-1 |
| KCNK17 | K2p17.1 | TALK[2][3] | TALK-2, TASK-4 |
| KCNK18 | K2p18.1 | TRIK, TRESK[2][3][6][7] |
[edit] See also
[edit] References
- ^ a b Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106.
- ^ a b c d e f g h i j k l m Enyedi P, Czirják G (2010). "Molecular background of leak K+ currents: two-pore domain potassium channels". Physiological Reviews 90 (2): 559–605. doi:10.1152/physrev.00029.2009. PMID 20393194.
- ^ a b c d e f g h i j k l m Lotshaw DP (2007). "Biophysical, pharmacological, and functional characteristics of cloned and native mammalian two-pore domain K+ channels". Cell Biochemistry and Biophysics 47 (2): 209–56. doi:10.1007/s12013-007-0007-8. PMID 17652773.
- ^ Fink M, Lesage F, Duprat F, Heurteaux C, Reyes R, Fosset M, Lazdunski M (1998). "A neuronal two P domain K+ channel stimulated by arachidonic acid and polyunsaturated fatty acids". The EMBO Journal 17 (12): 3297–308. doi:10.1093/emboj/17.12.3297. PMC 1170668. PMID 9628867. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1170668.
- ^ Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (2001). "Potassium leak channels and the KCNK family of two-P-domain subunits". Nature Reviews Neuroscience 2 (3): 175–84. doi:10.1038/35058574. PMID 11256078.
- ^ Sano Y, Inamura K, Miyake A, Mochizuki S, Kitada C, Yokoi H, Nozawa K, Okada H, Matsushime H, Furuichi K (2003). "A novel two-pore domain K+ channel, TRESK, is localized in the spinal cord". The Journal of Biological Chemistry 278 (30): 27406–12. doi:10.1074/jbc.M206810200. PMID 12754259.
- ^ Czirják G, Tóth ZE, Enyedi P (2004). "The two-pore domain K+ channel, TRESK, is activated by the cytoplasmic calcium signal through calcineurin". The Journal of Biological Chemistry 279 (18): 18550–8. doi:10.1074/jbc.M312229200. PMID 14981085.
[edit] External links
- MeSH Tandem+Pore+Domain+Potassium+Channel
- "Two-P Potassium Channels". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/IC/FamilyMenuForward?familyId=18.
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