Tynorphin

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Tynorphin
Tynorphin.svg
Systematic (IUPAC) name
(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-indol-3-yl)propanoic acid
Clinical data
Legal status
  • Non-regulated
Identifiers
ATC code None
PubChem CID 9961318
ChemSpider 8136925
Chemical data
Formula C35H46N6O7 
Mol. mass 662.8 g/mol

Tynorphin is a synthetic opioid peptide which is a potent and competitive inhibitor of the enkephalinase class of enzymes which break down the endogenous enkephalin peptides.[1] It specifically inactivates dipeptidyl aminopeptidase III (DPP3) with very high efficacy, but also inhibits neutral endopeptidase (NEP), aminopeptidase N (APN), and angiotensin-converting enzyme (ACE) to a lesser extent.[1] It has a pentapeptide structure with the amino acid sequence Val-Val-Tyr-Pro-Trp.

Tynorphin was discovered in an attempt to develop an enkephalinase inhibitor of greater potency than spinorphin.[1]

See also[edit]

References[edit]

  1. ^ a b c Yamamoto Y, Hashimoto J, Shimamura M, Yamaguchi T, Hazato T (April 2000). "Characterization of tynorphin, a potent endogenous inhibitor of dipeptidyl peptidaseIII". Peptides 21 (4): 503–8. doi:10.1016/S0196-9781(00)00174-1. PMID 10822105.