Type II collagen

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collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital)
Symbol COL2A1
Alt. symbols SEDC
Entrez 1280
HUGO 2200
OMIM 120140
RefSeq NM_001844
UniProt P02458
Other data
Locus Chr. 12 q13.11-q13.2

Type II collagen is the basis for articular cartilage and hyaline cartilage.

It makes up 50% of all protein in cartilage and 85-90% of collagen of articular cartilage.

Type II collagen does form fibrils. This fibrillar network of collagen allows cartilage to entrap the proteoglycan aggregate as well as provide tensile strength to the tissue.

Treatment of rheumatoid arthritis[edit]

According to a study[1] published in the journal Science, oral administration of type II collagen improves symptoms of rheumatoid arthritis. The authors conducted a randomized, double-blind trial involving 60 patients with severe, active rheumatoid arthritis. A decrease in the number of swollen joints and tender joints occurred in subjects fed with chicken type II collagen for 3 months, but not in those that received a placebo. Four patients in the collagen group had complete remission of the disease. No side effects were evident.

Hydrolyzed type II collagen on osteoarthritis[edit]

A published study reports that the oral intake of BioCell Collagen, hydrolyzed type II collagen naturally coexisting with chondroitin sulfate and hyaluronic acid, reduces joint discomfort. A randomized controlled trial (RCT) enrolling 80 subjects demonstrated that BioCell Collagen was well tolerated with no serious adverse event and led to a significant improvement of chronic joint discomfort.[2] More studies need to be performed to confirm the observation. A potential mechanism for the joint health benefit may be due to the stimulation of biosynthesis of collagen type II from the chondrocytes in the cartilage,[3] where hydrolyzed collagen appears to be accumulated.


  1. ^ Trentham, D.; Dynesius-Trentham, R.; Orav, J.; Combitchi, D.; Lorenzo, C.; Sewell, K.; Hafler, D. & Weiner, H. (1993). "Effects of Oral Administration of Type II Collagen on Rheumatoid Arthritis". Science 261 (5119): 1727–1730. doi:10.1126/science.8378772. 
  2. ^ Schauss, A., Stenehjem, J., Park, J., Endres, J., and Clewell, A. 2012. Effect of the novel low molecular weight hydrolyzed chicken sternal cartilage extract, BioCell Collagen, on improving osteoarthritis-related symptoms: a randomized, double-blind, placebo-controlled trial. Journal of Agricultural and Food Chemistry 60(16):4096-101. PMID 22486722.
  3. ^ Oesser, S.; Seifert, J. (2003). "Stimulation of type II collagen biosynthesis and secretion in bovine chondrocytes cultured with degraded collagen". Cell tissue research 311 (3): 393–399. doi:10.1007/s00441-003-0702-8. PMID 12658447. 

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