Type II collagen

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collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital)
Symbol COL2A1
Alt. symbols SEDC
Entrez 1280
HUGO 2200
OMIM 120140
RefSeq NM_001844
UniProt P02458
Other data
Locus Chr. 12 q13.11-q13.2

Type II collagen is the basis for articular cartilage and hyaline cartilage.

It makes up 50% of all protein in cartilage and 85-90% of collagen of articular cartilage.

Type II collagen does form fibrils. This fibrillar network of collagen allows cartilage to entrap the proteoglycan aggregate as well as provide tensile strength to the tissue.

Treatment of rheumatoid arthritis[edit]

According to a study[1] published in the journal Science, oral administration of type II collagen decreases symptoms of rheumatoid arthritis. The authors conducted a randomized, double-blind trial involving 60 patients with severe, active rheumatoid arthritis. A decrease in the number of swollen joints and tender joints occurred in subjects fed with chicken type II collagen for 3 months, but not in those that received a placebo. Four patients in the collagen group had complete remission of the disease. No side effects were evident.


  1. ^ Trentham, D.; Dynesius-Trentham, R.; Orav, J.; Combitchi, D.; Lorenzo, C.; Sewell, K.; Hafler, D. & Weiner, H. (1993). "Effects of Oral Administration of Type II Collagen on Rheumatoid Arthritis". Science 261 (5119): 1727–1730. doi:10.1126/science.8378772. 

See also[edit]

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