Typhoid vaccine

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Not to be confused with typhus vaccine.
Typhoid vaccine
Vaccine description
Target disease Typhoid
Clinical data
AHFS/Drugs.com monograph
MedlinePlus a607028
Legal status ?
Identifiers
CAS number  YesY
ATC code J07AP01 J07AP02 J07AP03
 N (what is this?)  (verify)

Typhoid vaccines are vaccines developed to prevent typhoid fever.

There are two effective types:[1]

Ty21a is licensed for use from age six years and older. Boosters are recommended every 5 years.[2] The Vi capsular polysaccharide vaccine is licensed for use from age two years and older, and boosters are required every three years.[3]

Almroth Edward Wright developed an effective inactivated whole-cell typhoid vaccine that was introduced in 1896.[1] Due to side-effects its usage was eventually discontinued.[3]

An experimental vaccine called Vi-rEPA has showed promising results in trials so far, indicating higher effectiveness and longer immunity. However, it has yet to be licensed for use.[1]

It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.[4]

Available preparations[edit]

References[edit]

  1. ^ a b c Fraser A, Goldberg E, Acosta CJ, Paul M, Leibovici L (2007). "Vaccines for preventing typhoid fever". Cochrane Database Syst Rev (3): CD001261. doi:10.1002/14651858.CD001261.pub2. PMID 17636661. 
  2. ^ http://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM142807.pdf
  3. ^ a b c d e Salisbury, D; Ramsay, M; Noakes, K. ""Chapter 33: Typhoid"". Immunisation against infectious disease. Department of Health. p. 418. ISBN 0-11-322528-8. 
  4. ^ "WHO Model List of EssentialMedicines". World Health Organization. October 2013. Retrieved 22 April 2014.