Tyrosine decarboxylase

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tyrosine decarboxylase
Identifiers
EC number 4.1.1.25
CAS number 9002-09-9
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a tyrosine decarboxylase (EC 4.1.1.25) is an enzyme that catalyzes the chemical reaction

L-tyrosine \rightleftharpoons tyramine + CO2

Hence, this enzyme has one substrate, L-tyrosine, and two products, tyramine and carbon dioxide.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is L-tyrosine carboxy-lyase (tyramine-forming). Other names in common use include L-tyrosine decarboxylase, L-(-)-tyrosine apodecarboxylase, and L-tyrosine carboxy-lyase. This enzyme participates in tyrosine metabolism and alkaloid biosynthesis. It employs one cofactor, pyridoxal phosphate.

References[edit]

  • McGilvery RW and Cohen PP (1948). "The decarboxylation of L-phenylalanine by Streptococcus faecalis R". J. Biol. Chem. 174 (3): 813–816. PMID 18871240.