U.S. Route 378

U.S. Route 378
Route information
Auxiliary route of US 78
Length:	234 mi (377 km)
Existed:	1952 – present
Major junctions
West end:	US 78 / SR 10 / SR 17 / SR 47 at Washington, GA
	US 178 in Saluda, SC US 1 in Lexington, SC I-20 in Columbia, SC I-77 in Columbia, SC I-26 in W. Columbia, SC US 76 in Sumter, SC US 15 in Sumter, SC I-95 near Turbeville, SC US 52 in Lake City, SC
East end:	US 501 / US 701 at Conway, SC
Highway system
United States Numbered Highways List • Bannered • Divided • Replaced

U.S. Route 378 (US 378) is a spur of US 78. It runs for 234 miles (377 km) from Conway, South Carolina at US 501 to Washington, Georgia at US 78.

Route description

US 378 passes through the states of South Carolina and Georgia.

South Carolina

In South Carolina, US 378 provides an important link between Columbia and the cities of Sumter, Lexington, and Saluda.

US 378 and US 1 run concurrent in Lexington for a short while before diverging.

In West Columbia, US 378 runs concurrent with US 1 again. The two roads cross over the Congaree River and enter Columbia.

In Columbia, US 378 runs concurrent with US 76 for approximately 40 miles (64 km) until they diverge in Sumter.

Major Intersections

Georgia

• US 78 / SR 10 / SR 17 / SR 47 in Washington, GA Western terminus
• SR 220 near Metasville, GA
• SR 43 / SR 47 in Lincolnton, GA

South Carolina

• US 221 / SC 28 / SC 10 in McCormick, SC
• SC 67 outside of Callison, SC
• US 25 outside of Owdoms, SC
• SC 430 outside of Owdoms, SC
• US 178 / SC 39 / SC 194 / SC 121 in Saluda, SC
• SC 391 east of Saluda, SC
• US 1 / SC 6 in Lexington, SC
• I-20 near Lexington, SC (EXIT 61)
• I-26 near W. Columbia, SC
• SC 12 in Columbia, SC
• SC 2 in Columbia, SC
• US 1 / US 76 / US 21 / US 321 in Columbia, SC
• SC 262 / I-77 near Columbia, SC
• SC 768 in Lykes, SC
• SC 769 in Horrell Hill, SC
• SC 764 near Eastover, SC
• US 601 near Eastover, SC
• SC 263 near Eastover, SC
• SC 261 in Stateburg, SC
• SC 441 near Stateburg, SC
• US 521 in Sumter, SC
• US 15 in Sumter, SC
• US 401 in Sumter, SC
• SC 763 near Sumter, SC
• SC 527 / SC 53 / I-95 in Turbeville, SC
• SC 341 / US 52 in Lake City, SC
• SC 51 / SC 41 between Kingsburg, SC and Gresham, SC (Short multiplexes)
• SC 908 near Brittons Neck, SC
• US 501 / US 701 in Conway, SC Eastern terminus