The total length of the southernmost segment of U.S. Route 59 that passes through Texas and terminates near the Mexican border is some 615 miles.
| County |
Location |
#
Mile |
Junction |
Notes |
| Webb |
Laredo |
|
I-35 – San Antonio |
|
|
Loop 20 (Bob Bullock Loop) |
|
|
|
FM 2895 |
|
|
|
FM 2050 |
|
| Duval |
|
|
SH 44 west – Encinal |
South end of SH 44 concurrency |
| Freer |
|
SH 16 (Norton Avenue) – Hebbronville, Tilden, San Antonio |
|
|
|
SH 44 east – Alice, Corpus Christi |
North end of SH 44 concurrency |
|
|
FM 2359 |
|
| McMullen |
No major junctions in McMullen County |
| Live Oak |
|
|
FM 624 |
|
|
|
FM 1359 |
|
|
|
FM 3336 |
|
| George West |
|
US 281 (Nueces Street) – Alice, San Antonio, McAllen |
|
|
|

US 59 Bus. |
|
|
|
FM 799 north |
South end of FM 799 concurrency |
|
|
FM 799 south |
North end of FM 799 concurrency |
|
|
I-37 – San Antonio, Corpus Christi |
|
|
|
FM 1596 |
|
| Bee |
|
|
FM 796 |
|
|
|
FM 1349 |
|
| Beeville |
|
FM 351 |
|
|
FM 673 (Minnesota Street) |
|
|
   
 US 181 Bus. / SH 202 (Washington Street) – Refugio |
|
|
US 181 – Sinton, Corpus Christi, Floresville, San Antonio |
|
| Goliad |
Berclair |
|
FM 883 |
|
|
|
FM 1351 |
|
|
|
SH 239 – Kenedy |
South end of SH 239 concurrency |
|
|
FM 1726 |
|
| Goliad |
|
  
  US 183 / US 77 Alt. / SH 239 (Jefferson Street) – Refugio, Austwell, Cuero, Austin |
North end of SH 239 concurrency |
| Fannin |
|
  FM 2987 / FM 2506 / PR 27 |
|
| Victoria |
|
|
 
 US 59 Bus. north (Moody Street) / Loop 463 (Zac Lentz Parkway) |
|
|
|
FM 446 |
|
|
|
US 77 – Hallettsville, Waco, Refugio, Brownsville |
|
|
|
Spur 91 |
|
| Victoria |
|
SH 185 – Bloomington, Port O'Connor |
|
|
US 87 – Cuero, San Antonio, Port Lavaca |
|
|
Loop 463 (Zac Lentz Parkway) |
|
|

US 59 Bus. south (Houston Highway) |
|
|
|
FM 1686 |
|
|
|
FM 444 |
|
| Jackson |
|
|
FM 234 |
|
|
|
 
 US 59 Bus. / Loop 521 north |
|
| Edna |
|
FM 822 |
|
|
SH 111 – Yoakum, Gonzales, Midfield |
Interchange |
|
|
 
 US 59 Bus. / Loop 521 south |
|
|
|
FM 530 – Hallettsville |
|
|
|
Loop 522 |
|
| Ganado |
|
 SH 172 / FM 710 |
Interchange |
|
|
Loop 522 |
|
| Wharton |
|
|
 Loop 523 / FM 647 |
|
|
|
FM 1160 |
Interchange |
|
|
Loop 523 |
|
|
|
 Loop 524 to FM 441 |
|
|
|
Loop 525 |
|
| El Campo |
|
FM 1163 (Palacios Street) |
Interchange |
|
SH 71 (Mechanic Street) – Columbus, LaGrange, Austin, Blessing |
Interchange |
|
FM 1162 (Blue Creek Road) |
Interchange |
|
 Loop 525 / FM 960 – Glen Flora |
Interchange |
|
|
Loop 526 |
|
| Wharton |
|
   
   US 59 Bus. to Loop 183 / FM 961 / SH 60 – Wharton |
Interchange |
|
 FM 102 to SH 60 – Eagle Lake, Bay City, Matagorda |
Interchange |
|
|
  
  US 59 Bus. / SH 60 / Loop 183 |
|
|
|
 FM 1161 to SH 60 |
Interchange |
|
|
  
  US 59 Bus. to Loop 183 / SH 60 – East Bernard, Wallis |
|
| Fort Bend |
|
|
FM 2919 |
|
|
|
Loop 541 |
Southbound exit and entrance |
|
|
FM 360 (Beasley-Needville Road) |
|
|
|
Loop 540 |
Southbound exit and entrance |
| Rosenberg |
|
Spur 10 |
Interchange |
| South end of freeway, South end of I-69 overlap |
|
Spur 529 |
|
|
Frontage Road |
Southbound exit and northbound entrance |
|
SH 36 – Rosenberg |
|
|
FM 2218 – Richmond |
|
|
Reading Road |
|
|
FM 762 – Richmond |
|
|
|
Williams Way Boulevard |
|
| Sugar Land |
|
 SH 99 (Grand Parkway) / FM 2759 (Crabb River Road) |
|
|
Brazos River Turnaround |
|
|
University Boulevard |
|
|
Sweetwater Boulevard, First Colony Boulevard |
|
|
SH 6 |
|
|
Sugar Lakes Drive, Williams Trace Boulevard |
|
|
Dairy Ashford Road, Sugar Creek Boulevard |
|
|

US 90 Alt. |
|
| Stafford |
|
Kirkwood Road, West Airport Boulevard |
|
| Harris |
Houston |
|
FM 1092 (Wilcrest Drive) / West Bellfort Avenue |
|
|
Sam Houston Tollway |
|
|
Beltway 8 (Frontage Road) |
Northbound exit is via the FM 1092 exit |
|
Bissonnet Street |
|
|
South Gessner Road, Beechnut Street |
|
|
Fondren Road, Bellaire Boulevard |
|
|
Hillcroft Avenue |
|
|
Westpark Tollway east |
Northbound exit only |
|
Westpark Tollway west |
Southbound exit and northbound entrance |
|
Westpark Drive |
Northbound exit is via the Hillcroft Avenue exit |
|
Fountainview Drive |
Southbound exit and northbound entrance |
|
Chimney Rock Road |
|
|
I-610 (West Loop Freeway) |
North end of I-69 overlap |
|
Newcastle Drive |
Northbound exit is via the Weslayan Road exit |
|
Weslayan Road |
|
|
Buffalo Speedway, Edloe Street |
|
|
Kirby Drive |
|
|
Greenbriar Drive, South Shepherd Drive |
|
|
Spur 527 north |
Northbound exit and southbound entrance |
|
Main Street |
Northbound exit and southbound entrance |
|
Fannin Street |
Southbound exit and northbound entrance |
|
SH 288 south (South Freeway) – Lake Jackson, Freeport |
|
|
McGowen Avenue, Tuam Avenue |
Southbound exit and northbound entrance |
|
I-45 (Gulf Freeway) – Dallas, Galveston |
|
|
Gray Avenue, Pierce Avenue; Downtown Houston |
Northbound exit and southbound entrance |
|
Polk Street – Downtown Houston |
Northbound exit only |
|
Jackson Street – Downtown Houston, George R. Brown Convention Center |
Southbound exit and northbound entrance |
|
I-10 (East Freeway) – San Antonio, Beaumont |
|
|
Lyons Avenue, Quitman Street |
|
|
Collingsworth Street, Cavalcade Street, Kelley Street |
|
|
Cavalcade Street |
Southbound exit and northbound entrance |
|
I-610 (North Loop Freeway) |
South end of I-69 overlap |
|
Crosstimbers Road, Kelley Street, Bennington Road |
|
|
Laura Koppe Road |
Southbound exit is via the Tidwell Road exit |
|
Tidwell Road |
|
|
Parker Road, Saunders Road, Jensen Drive |
|
|
Little York Road |
|
|
|
Hopper Road |
Northbound exit is via the Little York Road exit |
|
|
East Mount Houston Road |
|
|
|
Aldine Mail Route |
|
|
|
Lauder Road |
Northbound exit is via the Aldine Mail Route exit |
|
|
Old Humble Road, Lee Road, Homestead Road |
Northbound exit and southbound entrance |
|
|
FM 525 (Aldine Bender Road) |
|
| Houston |
|
Beltway 8 west (Sam Houston Parkway) |
|
|
Beltway 8 (Frontage Road) |
Northbound exit is via FM 525 exit |
|
Greens Road |
|
|
Rankin Road |
|
|
Will Clayton Parkway – Bush Intercontinental Airport |
|
| Humble |
|
Frontage Road |
Northbound exit and southbound entrance |
|
 FM 1960 / FM 1960 Bus. – Humble |
|
|
Townsen Boulevard |
Northbound exit and southbound entrance |
|
|
Loop 494 / Hamblen Road / Sorters-McClellan Road |
Northbound exit and southbound entrance |
| Montgomery |
|
|
Kingwood Drive |
|
|
|
Northpark Drive |
|
|
|
FM 1314 – Porter, Conroe |
|
|
|
Community Drive |
|
|
|
FM 1485 – New Caney |
|
|
|
Loop 494 |
Southbound exit and northbound entrance |
|
|
Roman Forest Boulevard |
|
| Woodbranch |
|
SH 242 |
|
|
Local traffic only |
Southbound exit only |
|
|
Creekwood Lane |
|
| Splendora |
|
FM 2090 – Splendora |
|
|
|
East River Drive |
|
|
|
Fostoria Road |
|
| North end of freeway, North end of I-69 overlap |
| Liberty |
|
|
Loop 573 (Washington Avenue) – Cleveland |
Two exits northbound |
| Cleveland |
|
SH 105 – Cleveland, Conroe |
|
|
FM 2025 – Coldspring |
|
|
Loop 573 (Washington Avenue) – Cleveland |
|
| San Jacinto |
|
|
FM 2914 |
|
| Shepherd |
|
 Loop 424 (Byrd Avenue) / FM 3460 |
|
|
 SH 150 / FM 223 – Coldspring |
Interchange |
|
Loop 424 |
|
|
|
FM 1127 |
|
|
|
Loop 393 |
|
| Polk |
Goodrich |
|
FM 2665 |
|
|
FM 1988 |
|
|
Loop 393 |
|
| Livingston |
|

US 59 Bus. north (Pan American Drive) – Livingston, Woodville |
Southbound exit is part of exit 436A |
| 436A |
FM 1988 south – Lake Livingston State Park |
|
| 436D |
Frontage Road |
Northbound exit and southbound entrance |
| 434B |
Frontage Road |
Southbound exit and northbound entrance |
|
US 190 – Huntsville, Livingston |
|
| 432B |
Frontage Road – Pedigo Park |
Southbound exit and northbound entrance |
| 434D |
 
 US 59 Bus. south (Washington Avenue) to SH 146 south – Downtown Livingston, Pedigo Park |
|
|
|
Loop 116 |
|
| Leggett |
|
Loop 116 |
|
|
FM 942 |
Short concurrency with FM 942 in Leggett |
|
|
FM 62 |
|
|
|
Loop 177 |
|
|
|
FM 350 |
|
|
|
Loop 177 |
|
| Corrigan |
|
FM 942 |
|
|
US 287 (2nd Street) |
|
|
FM 352 |
|
|
FM 1987 |
|
| Angelina |
|
|
 FM 357 / FM 1987 |
|
| Diboll |
|
 Loop 210 (Thompson Street) / FM 1818 (Dennis Street) |
|
|
Loop 210 |
|
|
FM 2497 (Ryan Chapel Road) |
|
|
|
FM 2108 |
|
|
|
FM 324 |
|
| Lufkin |
|
FM 819 (College Drive) |
|
|
FM 1877 |
|
|
 
 US 59 Bus. (1st Street) / Loop 287 (John Redditt Drive) |
Interchange, south end of Loop 287 concurrency |
|
FM 58 (Chestnut Street) |
Interchange |
|
 
 US 69 (Woodville) / US 69 Bus. |
|
|
 FM 841 (Lufkin Avenue) to FM 325 |
Northbound exit, southbound entrance |
|
FM 841 (Ford Chapel Road) |
Southbound exit, northbound entrance |
|
FM 325 (Lufkin Avenue) |
Southbound exit, northbound entrance |
|
SH 103 (Atkinson Drive) |
Interchange |
|
  
  US 69 / US 59 Bus. (Timberland Drive) / Loop 287 (Ellen Trout Drive) |
North end of US 69 / Loop 287 concurrency |
|
|
FM 3521 |
|
|
|
FM 3439 |
|
|
|
FM 2021 |
|
|
|
FM 843 |
|
| Nacogdoches |
Nacogdoches |
|
 
 US 59 Bus. (South Street) / Loop 224 (Stallings Drive) |
Interchange, south end of Loop 224 concurrency |
|
SH 7 (Fredonia Street) |
Interchange |
|
FM 225 (Durst Street) |
Interchange |
|
SH 21 (Douglass Road) |
Interchange |
|
FM 2609 (Austin Street) |
|
|
 FM 1638 (Old Tyler Road) to FM 3314 (Lone Star Road) |
Interchange |
|
Loop 224 (Stallings Drive) / Westward Drive |
Interchange, north end of Loop 224 concurrency |
|
|
FM 342 (Industrial Drive) |
|
|
|
 
 US 259 north / US 59 Bus. south – Henderson, Nacogdoches |
Interchange |
|
|
FM 2864 |
|
| Appleby |
|
FM 941 (Appleby Sand Road) |
|
|
|
FM 2476 (Fitze Road) |
|
| Garrison |
|
FM 95 |
|
|
FM 138 (Greenwood Street) |
|
|
FM 95 (Main Street) |
|
| Rusk |
No major junctions in Rusk County |
| Shelby |
|
|
FM 2667 |
|
| Timpson |
|
US 84 |
South end of US 84 concurrency |
|
SH 87 |
|
|
FM 947 (Tennessee Road) |
|
|
Spur 470 (Bear Drive) |
|
|
|
FM 1645 |
|
| Tenaha |
|
FM 2141 |
|
|
FM 947 (Main Street) |
|
|
Loop 157 (Center Street) |
|
|
 US 84 east (George Bowers Drive) / US 96 south – Center |
Interchange, north end of US 84 concurrency |
|
Loop 157 (Center Street) |
|
| Panola |
|
|
FM 999 |
|
|
|
FM 2517 |
|
|
|
 
 US 59 Bus. (Shelby Street) / SH 149 (LaSalle Parkway) |
Interchange |
| Carthage |
|
FM 699 (Forsythe Street) |
|
|
 
 US 79 / US 79 Bus. (Sabine Street) |
Interchange, south end of US 79 concurrency |
|
|
 
 US 79 (LaSalle Parkway) / US 59 Bus. |
Interchange, north end of US 79 concurrency |
|
|
FM 124 |
|
|
|
FM 2792 |
|
|
|
FM 1794 |
|
| Harrison |
|
|
FM 1186 |
|
|
|
FM 2983 |
|
|
|
FM 2625 |
|
| Marshall |
|
I-20 – Dallas, Shreveport |
|
|
SH 43 (Pinecrest Drive) |
South end of SH 43 concurrency |
|
FM 31 (Travis Street) |
|
|
US 80 (Grand Avenue / Victory Drive) |
|
|
SH 43 (Karnack Highway) |
North end of SH 43 concurrency |
|
Loop 390 (Ernest F. Smith Parkway) |
|
|
|
FM 1793 |
|
| Woodlawn |
|
FM 1997 |
|
| Marion |
|
|
FM 2208 |
|
| Jefferson |
|
SH 49 (Broadway Street) |
|
|
|
FM 1324 |
|
| Cass |
|
|
FM 2683 |
|
| Linden |
|
  SH 8 / SH 155 / FM 125 (Main Street) |
|
|
FM 125 (Kildare Road) |
|
|
FM 1841 |
|
|
FM 1913 |
|
|
|
SH 11 (Houston Street) |
|
|
|
FM 1913 |
|
|
|
FM 2328 |
|
|
|
FM 2328 |
|
| Atlanta |
|
SH 77 |
South end of SH 77 concurrency |
|
 SH 77 (Pine Crest Drive) / FM 249 (Main Street) |
North end of SH 77 concurrency |
|
SH 43 (Louise Street) |
|
|
 Loop 236 / FM 2791 (Hickory Street) |
|
|
FM 96 (Lanark Street) |
|
|
FM 2914 |
|
|
Loop 236 |
|
|
|
FM 2327 |
|
|
|
FM 2327 |
|
|
|
FM 3129 |
|
| Bowie |
|
|
FM 2148 |
|
|
|
FM 3244 |
|
|
|
FM 2516 (Buchanan Loop Road) |
|
|
|
FM 989 (Kings Highway) |
|
| Texarkana |
|
 SH 93 (Lake Drive) / Loop 151 (Wallace Parkway) |
|
|
South end of freeway |
|
US 67 (7th Street) |
|
|
Westlawn Drive – Wake Village |
|
|
US 82 (New Boston Road) |
|
|
I-30 west – Dallas |
South end of I-30 concurrency |
| 220B |
FM 559 (Richmond Road) |
|
| 222 |
 SH 93 / FM 1397 (Summerhill Road) |
|
| 223A |
 I-30 east / US 71 south (State Line Avenue) – Little Rock |
Northbound exit ramp enters Arkansas, north end of I-30 concurrency, south end of US 71 concurrency |
| North end of freeway. Continues into Arkansas |